Association between nesfatin-1 hormone levels, anthropometric measurements, and glucose regulation shortly after sleeve gastrectomy: A cross-sectional study

IF 0.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM International Journal of Diabetes in Developing Countries Pub Date : 2023-12-11 DOI:10.1007/s13410-023-01297-y

Ayşegül Sivaslıoğlu, Hakan Buluş, Doğan Öztürk, Evrim Kahramanoğlu Aksoy, Zeynep Göktaş

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Abstract

Objective

This cross-sectional study was planned to evaluate the relationship between serum nesfatin-1 levels, glucose regulation and anthropometric measurements of individuals who had undergone sleeve gastrectomy.

Methods

A total of 40 participants aged between 19 and 64 years with a body mass index (BMI) greater than 30 kg/m² who underwent sleeve gastrectomy participated in the study. Before and 1 month after the surgery, serum nesfatin-1, fasting insulin levels, anthropometric measurements and biochemical parameters were assessed.

Results

Serum nesfatin-1 levels significantly decreased 4 weeks after the surgery (108.3 ± 58.35 pg/mL versus 74.6 ± 40.12 pg/mL: p = 0.003). Serum insulin levels (µIU/ml) showed a similar decrease (p < 0.001). Change in serum nesfatin-1 levels significantly correlated with change in BMI and body fat mass (p = 0.009, p = 0.007, respectively). Furthermore, serum nesfatin-1 levels significantly correlated with total cholesterol levels (p = 0.037). However, despite the significant decreases in both nesfatin-1 levels and glucose regulation markers, no correlation was found between them. The significant decrease observed in post-operative serum nesfatin-1 levels was found to be correlated with anthropometric measurements.

Conclusions

This finding highlights the anorexigenic effects of nesfatin-1, and therefore, nesfatin-1 may be an effective factor in obesity treatment and diabetes.

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袖带胃切除术后短期内内司芬-1 激素水平、人体测量指标与血糖调节之间的关系：横断面研究

目的本横断面研究计划评估接受袖状胃切除术者的血清nesfatin-1水平、血糖调节和人体测量指标之间的关系。方法共有40名年龄在19至64岁之间、体重指数（BMI）大于30 kg/m2、接受袖状胃切除术的参与者参与了研究。结果手术 4 周后，血清奈斯法汀-1 水平显著下降（108.3 ± 58.35 pg/mL 对 74.6 ± 40.12 pg/mL：P = 0.003）。血清胰岛素水平（µIU/ml）也出现了类似的下降（p = 0.001）。血清nesfatin-1水平的变化与体重指数（BMI）和体脂量的变化显著相关（分别为p = 0.009和p = 0.007）。此外，血清内司蛋白-1 水平与总胆固醇水平有明显相关性（p = 0.037）。然而，尽管奈斯法丁-1水平和葡萄糖调节指标都有明显下降，但它们之间却没有发现相关性。结论：这一发现凸显了奈斯法丁-1的厌食作用，因此奈斯法丁-1可能是治疗肥胖症和糖尿病的有效因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Diabetes in Developing Countries ENDOCRINOLOGY & METABOLISM-

CiteScore

1.60

自引率

0.00%

发文量

109

审稿时长

6 months

期刊介绍： International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.