Increased Susceptibility to Pilocarpine-Induced Status Epilepticus and Reduced Latency in TRPC1/4 Double Knockout Mice

IF 3.2 Q2 CLINICAL NEUROLOGY Neurology International Pub Date : 2023-12-06 DOI:10.3390/neurolint15040095
Fang Zheng, Kevin D. Phelan, U. T. Shwe
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Abstract

Canonical transient receptor potential channels (TRPCs) are a family of calcium-permeable cation channels. Previous studies have shown that heteromeric channels comprising TRPC1 and TRPC4 mediate epileptiform bursting in lateral septal neurons and hippocampal CA1 pyramidal neurons, suggesting that TRPC1/4 channels play a pro-seizure role. In this study, we utilized electroencephalography (EEG) recording and spectral analysis to assess the role of TRPC1/4 channels in the pilocarpine model of status epilepticus (SE). We found that, surprisingly, TRPC1/4 double knockout (DKO) mice exhibited an increased susceptibility to pilocarpine-induced SE. Furthermore, SE latency was also significantly reduced in TRPC1/4 DKO mice. Further studies are needed to reveal the underlying mechanisms of our unexpected results.
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TRPC1/4 双基因敲除小鼠对皮洛卡品诱发癫痫状态的易感性增加和潜伏期缩短
典型瞬时受体电位通道(trpc)是一类钙渗透阳离子通道。先前的研究表明,由TRPC1和TRPC4组成的异质通道介导侧间隔神经元和海马CA1锥体神经元的癫痫样爆裂,表明TRPC1/4通道起促癫痫发作作用。在这项研究中,我们利用脑电图(EEG)记录和频谱分析来评估TRPC1/4通道在匹洛卡平癫痫持续状态(SE)模型中的作用。我们发现,令人惊讶的是,TRPC1/4双敲除(DKO)小鼠对匹罗卡品诱导的SE的易感性增加。此外,TRPC1/4 DKO小鼠的SE潜伏期也显著降低。需要进一步的研究来揭示我们意想不到的结果的潜在机制。
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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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