HISTOLOGICAL EVALUATION OF ANGELICA SINENSIS IN MANAGEMENT OF CLASS II FURCATION DEFECT (AN EXPERIMENTAL STUDY)

Abstract

INTRODUCTION: proper management of furcation involvements has always been a demanding issue in periodontal therapy. Herbal medicine is nowadays proposed to provide novel alternative approaches for restoring defective bone. A Chinese herb known as Angelica sinensis (As) has various pharmacological effects as it promotes proliferation and differentiation of osteoblasts OBJECTIVES: The aim of this study was to evaluate the effectiveness of Angelica sinensis in conjunction with β -tricalcium phosphate in the management of class II furcation defects in dogs MATERIALS AND METHODS: This randomized study was carried on 6 clinically healthy mongrel dogs. 24 grade II critical-sized furcation defects were surgically created in the mandibular third and fourth premolars. 12 defects were filled with Beta-tricalcium phosphate (β -TCP) bone gr aft only (control group). While in the other 12 defects β -TCP was mixed with Angelica sinensis powder (experimental group). The defects were covered by collagen membrane, The dogs were sacrificed at 4 and 8 weeks postoperative. RESULTS: The histological analysis has revealed better regenerative features regarding alveolar bone, periodontal ligament and cementum in the experimental groups when compared to control groups. CONCLUSIONS: Angelica sinensis herb could enhance the periodontal regenerative potential of β -TCP bone graft.