Designing microbial cell factories for programmable control of cellular metabolism

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Opinion in Systems Biology Pub Date : 2023-12-04 DOI:10.1016/j.coisb.2023.100493

Soo Young Moon , So-Hee Son , Seung-Ho Baek , Ju Young Lee

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Abstract

Synthetic biology has promoted a conceptual shift in metabolic engineering for the microbial production of industrial chemicals toward a sustainable economy. Engineering principles from synthetic biology and metabolic engineering are integrated to redesign cellular metabolism to create microbial cell factories with emerging and programmable functionalities. Combining metabolic engineering with programmed spatial control is a promising approach that enables deep rewiring of microbial cell factory metabolism for the efficient production of bio-based chemicals. In this review, we discuss metabolic compartmentalization approaches for programmable control of cellular metabolism, including intracellular or intercellular partitioning-based organization of biosynthetic pathways. We also examine the designs and applications of cellular compartments and their analogs, highlighting selected examples for creating efficient and sustainable microbial cell factories.

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设计可编程控制细胞代谢的微生物细胞工厂

合成生物学促进了代谢工程概念的转变，使工业化学品的微生物生产朝着可持续经济的方向发展。合成生物学的工程原理与代谢工程相结合，重新设计细胞代谢，创建具有新兴和可编程功能的微生物细胞工厂。将代谢工程与程序化空间控制相结合是一种很有前景的方法，它能深度重构微生物细胞工厂的新陈代谢，从而高效生产生物基化学品。在本综述中，我们将讨论可编程控制细胞代谢的代谢分区方法，包括基于细胞内或细胞间分区的生物合成途径组织。我们还研究了细胞区室及其类似物的设计和应用，重点介绍了用于创建高效、可持续微生物细胞工厂的部分实例。

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来源期刊

Current Opinion in Systems Biology Mathematics-Applied Mathematics

CiteScore

7.10

自引率

2.70%

发文量

期刊介绍： Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution