{"title":"A rare case of MET exon 14 skipping mutation-positive pulmonary sarcomatoid carcinoma with pancreatic metastasis","authors":"Tatsuya Hayashi , Shinji Otani , Riko Kitazawa , Takashi Ueki , Takao Ishimura , Takahito Sugihara , Fumiya Ogura , Yousuke Kiriyama , Yu Mori , Nobuhiko Sakao , Yoshifumi Sano , Hironori Izutani","doi":"10.1016/j.rmcr.2023.101956","DOIUrl":null,"url":null,"abstract":"<div><p>Lung sarcomatoid carcinoma is a rare tumor. We report a rare case of pancreatic metastasis in a 76-year-old man with lung sarcomatoid carcinoma. Right upper lobectomy was performed, and the patient was diagnosed with pulmonary sarcomatoid carcinoma with a MET exon 14 skipping mutation. A biopsy of the pancreatic lesion subsequently revealed pancreatic metastasis. A MET exon 14 skipping mutation was confirmed, and the patient was treated with a MET tyrosine kinase inhibitor and maintained a complete response for 2 years. Lung sarcomatoid carcinoma rarely metastasizes to the pancreas and can be adequately treated with a MET tyrosine kinase inhibitor.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221300712300151X/pdfft?md5=268fca279106914f2a74795759a36553&pid=1-s2.0-S221300712300151X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Medicine Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221300712300151X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Lung sarcomatoid carcinoma is a rare tumor. We report a rare case of pancreatic metastasis in a 76-year-old man with lung sarcomatoid carcinoma. Right upper lobectomy was performed, and the patient was diagnosed with pulmonary sarcomatoid carcinoma with a MET exon 14 skipping mutation. A biopsy of the pancreatic lesion subsequently revealed pancreatic metastasis. A MET exon 14 skipping mutation was confirmed, and the patient was treated with a MET tyrosine kinase inhibitor and maintained a complete response for 2 years. Lung sarcomatoid carcinoma rarely metastasizes to the pancreas and can be adequately treated with a MET tyrosine kinase inhibitor.
肺肉瘤样癌是一种罕见肿瘤。我们报告了一例罕见的胰腺转移病例，患者是一名 76 岁的男性，患有肺肉瘤样癌。患者接受了右上肺叶切除术，被诊断为肺肉瘤样癌，并伴有 MET 第 14 号外显子跳越突变。随后进行的胰腺病灶活检发现了胰腺转移。患者接受了 MET 酪氨酸激酶抑制剂治疗，并在两年内保持了完全应答。肺肉瘤样癌很少转移到胰腺，使用MET酪氨酸激酶抑制剂就能得到充分治疗。
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
