Cardiovascular diseases and the heart–gut cross talk

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Indian heart journal Pub Date : 2024-03-01 DOI:10.1016/j.ihj.2023.12.003

Snehali Majumder , Rohan Kiritkumar Makwana , Varun Shetty , Suparna Mukherjee , Pradeep Narayan

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Abstract

The purpose of this narrative review is to provide a comprehensive overview of current research on heart-gut cross talk and its implications for cardiovascular disease. To uncover relevant preclinical and clinical research examining heart-gut cross talk, a thorough literature search was undertaken utilising electronic databases. The chosen publications were critically examined, and major findings were synthesised to offer a thorough perspective on the subject. We want to synthesise the most recent study findings, explain the underlying mechanisms, and provide potential treatment techniques. By exploring bidirectional connection between the heart and the gut, we shed light on novel future options for the prevention and treatment of cardiovascular diseases. The heart-gut cross talk is an exciting field of study with implications for cardiovascular disease. Understanding the complex connection between the heart and the gastrointestinal tract may lead to the development of novel therapeutic targets and therapies for the prevention and management of cardiovascular diseases. Future research should concentrate on identifying the specific processes driving this crosstalk as well as assessing the efficacy of therapies targeting the gut microbiota and the gut–brain axis in improving cardiovascular outcomes.

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心血管疾病与心脏-肠道交叉对话

这篇叙述性综述旨在全面概述当前有关心脏-肠道交叉对话及其对心血管疾病影响的研究。为了揭示检查心脏-肠道交叉对话的相关临床前和临床研究，我们利用电子数据库进行了全面的文献检索。我们对所选出版物进行了严格审查，并对主要研究结果进行了综合，以提供有关该主题的全面观点。我们希望综合最新的研究结果，解释其基本机制，并提供潜在的治疗技术。通过探索心脏与肠道之间的双向联系，我们为预防和治疗心血管疾病提供了新的未来选择。心脏-肠道交叉对话是一个令人兴奋的研究领域，对心血管疾病具有重要影响。了解心脏和胃肠道之间的复杂联系可能有助于开发预防和治疗心血管疾病的新型治疗靶点和疗法。未来的研究应集中于确定驱动这种串扰的特定过程，以及评估针对肠道微生物群和肠道-大脑轴的疗法在改善心血管预后方面的疗效。

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来源期刊

Indian heart journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

52 days

期刊介绍： Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.