Mesenchymal Stem Cells Applications in Alzheimer's Disease

IF 1.2 Q4 GENETICS & HEREDITY Global Medical Genetics Pub Date : 2023-12-01 DOI:10.1055/s-0043-1777087
Oluwatosin Debola Oyebode, P. Tulay
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Abstract

Abstract Alzheimer's disease (AD) is a neurodegenerative disorder that advances gradually and primarily impacts the hippocampus region of the brain. It is defined by a deterioration in cognitive function as well as an observable loss of memory retention. One of the major characteristics of AD is the impairment of neural generation, resulting in the depletion of neurons and synaptic connections within the nervous system. It is unfortunate to say that, at present, no definitive cure is available for AD, and no medication is effective in halting the progression of neurodegeneration associated with it. Nevertheless, it is crucial to highlight that progress has been achieved in addressing the troubling symptoms of AD. The Food and Drug Administration has granted approval for two categories of medications designed to alleviate these symptoms. The scientific community has been inspired by these advancements to investigate alternative therapeutic options, with an emphasis on stem cell therapy in particular. The main focus of this review will be on the potential for the use of a variety of mesenchymal stem cells as a treatment for AD.
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间充质干细胞在阿尔茨海默病中的应用
阿尔茨海默病(AD)是一种逐渐进展的神经退行性疾病,主要影响大脑海马区。它的定义是认知功能的恶化以及可观察到的记忆保留能力的丧失。阿尔茨海默病的主要特征之一是神经生成障碍,导致神经系统内神经元和突触连接的耗竭。不幸的是,目前,阿尔茨海默病还没有明确的治疗方法,也没有药物能有效地阻止与阿尔茨海默病相关的神经退行性疾病的进展。然而,必须强调的是,在解决阿尔茨海默病令人不安的症状方面取得了进展。美国食品和药物管理局已经批准了两类旨在缓解这些症状的药物。科学界受到这些进步的启发,开始研究替代治疗方案,特别是干细胞治疗。这篇综述的主要焦点将是利用各种间充质干细胞治疗阿尔茨海默病的潜力。
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来源期刊
Global Medical Genetics
Global Medical Genetics GENETICS & HEREDITY-
自引率
11.80%
发文量
30
审稿时长
14 weeks
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