Ying-Rong Chen, Xiang Yu, Li-Min Xu, Jue Mei, Meng-Li Tian, Min Xu, Qiu-Yue Jin, Li-Bing Ye, Shui-Xin Yang
{"title":"Effect of Genetic Polymorphisms on the Pharmacokinetics of Gefitinib in Healthy Chinese Volunteers","authors":"Ying-Rong Chen, Xiang Yu, Li-Min Xu, Jue Mei, Meng-Li Tian, Min Xu, Qiu-Yue Jin, Li-Bing Ye, Shui-Xin Yang","doi":"10.1080/00498254.2023.2294039","DOIUrl":null,"url":null,"abstract":"Gefitinib is the first generation drug of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) metabolized by the cytochrome P450 and transported by P-glycoprotein (ABCB1) and br...","PeriodicalId":23812,"journal":{"name":"Xenobiotica","volume":"18 1","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Xenobiotica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00498254.2023.2294039","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Gefitinib is the first generation drug of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) metabolized by the cytochrome P450 and transported by P-glycoprotein (ABCB1) and br...
期刊介绍：
Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
