Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth

IF 4.3 2区医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2023-12-15 DOI:10.1016/j.ynstr.2023.100599

Mikki Schantell , Brittany K. Taylor , Amirsalar Mansouri , Yasra Arif , Anna T. Coutant , Danielle L. Rice , Yu-Ping Wang , Vince D. Calhoun , Julia M. Stephen , Tony W. Wilson

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Abstract

Background

Psychosocial distress among youth is a major public health issue characterized by disruptions in cognitive control processing. Using the National Institute of Mental Health's Research Domain Criteria (RDoC) framework, we quantified multidimensional neural oscillatory markers of psychosocial distress serving cognitive control in youth.

Methods

The sample consisted of 39 peri-adolescent participants who completed the NIH Toolbox Emotion Battery (NIHTB-EB) and the Eriksen flanker task during magnetoencephalography (MEG). A psychosocial distress index was computed with exploratory factor analysis using assessments from the NIHTB-EB. MEG data were analyzed in the time-frequency domain and peak voxels from oscillatory maps depicting the neural cognitive interference effect were extracted for voxel time series analyses to identify spontaneous and oscillatory aberrations in dynamics serving cognitive control as a function of psychosocial distress. Further, we quantified the relationship between psychosocial distress and dynamic functional connectivity between regions supporting cognitive control.

Results

The continuous psychosocial distress index was strongly associated with validated measures of pediatric psychopathology. Theta-band neural cognitive interference was identified in the left dorsolateral prefrontal cortex (dlPFC) and middle cingulate cortex (MCC). Time series analyses of these regions indicated that greater psychosocial distress was associated with elevated spontaneous activity in both the dlPFC and MCC and blunted theta oscillations in the MCC. Finally, we found that stronger phase coherence between the dlPFC and MCC was associated with greater psychosocial distress.

Conclusions

Greater psychosocial distress was marked by alterations in spontaneous and oscillatory theta activity serving cognitive control, along with hyperconnectivity between the dlPFC and MCC.

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为认知控制提供服务的 Theta 振荡动态指标：青少年的社会心理困扰

背景青少年的心理社会困扰是一个重大的公共卫生问题，其特点是认知控制处理过程受到干扰。我们利用美国国家心理健康研究所的研究领域标准（RDoC）框架，量化了青少年认知控制过程中心理社会困扰的多维神经振荡标记。方法样本由 39 名青少年组成，他们在脑磁图（MEG）检查中完成了美国国家心理健康研究所工具箱情绪测试（NIHTB-EB）和埃里克森侧翼任务。通过对 NIHTB-EB 的评估结果进行探索性因子分析，计算出了社会心理压力指数。我们对脑磁图数据进行了时频域分析，并从描绘神经认知干扰效应的振荡图中提取峰值体素进行体素时间序列分析，以确定认知控制动态中的自发和振荡畸变与社会心理压力的关系。此外，我们还量化了社会心理压力与支持认知控制的区域之间的动态功能连接之间的关系。在左侧背外侧前额叶皮层 (dlPFC) 和中扣带回皮层 (MCC) 发现了 Theta 波段神经认知干扰。对这些区域的时间序列分析表明，较大的社会心理压力与前额叶皮层（dlPFC）和扣带回皮层（MCC）的自发活动升高以及扣带回皮层（MCC）的θ振荡减弱有关。最后，我们发现，dlPFC 和 MCC 之间更强的相位一致性与更严重的心理社会困扰有关。结论更严重的心理社会困扰表现为认知控制的自发和振荡θ活动的改变，以及 dlPFC 和 MCC 之间的超连接性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

9.40

自引率

4.00%

发文量

审稿时长

48 days

期刊介绍： Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.