Keita Nakatsutsumi, Koji Morishita, Todd W Costantini, Tomohiro Adachi, Akira Suekane, Keisuke Suzuki, Mitsuaki Kojima, Makoto Arita, Yasuhiro Otomo
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引用次数: 0
Abstract
Disruption of intestinal barrier caused by intestinal ischemia due to hemorrhagic shock, is associated with the pathogenesis of multiple organ dysfunction (MOD) after severe trauma. Mesenteric lymph (ML) plays an important role as a route for transporting inflammatory mediators, including lipids. Post-biotics, such as 10-hydroxy-cis-12-octadecenoic acid (HYA), have received much attention as a treatment option. However, the relationship between post-biotics and MOD has yet to be clarified. The aim of the present study is to analyze lipid metabolites derived from gut microbiota in the intestinal ischemia/reperfusion (IR) rat model.
失血性休克导致的肠道缺血会破坏肠道屏障，这与严重创伤后多器官功能障碍（MOD）的发病机制有关。肠系膜淋巴（ML）作为运输炎症介质（包括脂质）的途径发挥着重要作用。生物后药物，如 10-羟基-顺式-12-十八碳烯酸（HYA），作为一种治疗选择受到广泛关注。然而，后生物制剂与 MOD 之间的关系尚未明确。本研究旨在分析肠道缺血再灌注（IR）大鼠模型中来自肠道微生物群的脂质代谢物。
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