Effects of antipsychotics on amino acid levels in patients with first-episode schizophrenia: A prospective study

IF 2.5 4区医学 Q2 PSYCHIATRY European Journal of Psychiatry Pub Date : 2023-12-15 DOI:10.1016/j.ejpsy.2023.100229

X. Wang , L. Wang , Y. Xue , Y. Li

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Abstract

Background and objectives

Alterations in the molecular mechanisms of specific amino acids (AAs) may be implicated in the pathophysiology of schizophrenia (SZ). However, little is known about antipsychotic drugs influence on levels of AAs. This study aimed to further explore antipsychotics' effects on AAs and serum lipid levels in first-episode SZ.

Methods

Eighty subjects with the International Classification of Diseases, Tenth Edition (ICD-10) criteria-defined SZ were enrolled. The levels of 31 AAs were measured in plasma samples using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).

Results

Ten AAs (i.e., citrulline, sarcosine, tyrosine, leucine, proline, hydroxyproline, kynurenine, tryptophan, valine and isoleucine) were observed to be higher and three AAs (i.e., GABA, aminobutyric acid and asparaginic acid) were lower in 80 patients with first-episode SZ after various antipsychotics treatment. In addition, there were 1 out of 31 AAs altered after olanzapine treatment and there were only 2 out of 31 AAs altered after risperidone treatment. Furthermore, serum triglyceride (TG) was markedly upregulated after olanzapine treatment, while Apolipoprotein A1 (ApoA1) was generally upregulated after risperidone treatment in patients with first-episode SZ.

Conclusions

Taken together, antipsychotic treatment can affect the plasma levels of AAs in patients with first-episode SZ, and olanzapine and risperidone have differential effects on the levels of AAs.

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抗精神病药物对首发精神分裂症患者氨基酸水平的影响：前瞻性研究

背景和目的特定氨基酸（AAs）分子机制的改变可能与精神分裂症（SZ）的病理生理学有关。然而，人们对抗精神病药物对氨基酸水平的影响知之甚少。本研究旨在进一步探讨抗精神病药物对首发 SZ 患者 AAs 和血清脂质水平的影响。采用超高效液相色谱-串联质谱法（UPLC-MS/MS）测量了血浆样本中 31 种 AAs 的水平、结果观察到 80 名首发 SZ 患者在接受各种抗精神病药物治疗后，10 种 AAs（瓜氨酸、肌氨酸、酪氨酸、亮氨酸、脯氨酸、羟脯氨酸、犬尿氨酸、色氨酸、缬氨酸和异亮氨酸）升高，3 种 AAs（GABA、氨基丁酸和天冬酰胺酸）降低。此外，奥氮平治疗后，31 个 AAs 中有 1 个发生变化，而利培酮治疗后，31 个 AAs 中只有 2 个发生变化。此外，奥氮平治疗后血清甘油三酯（TG）明显升高，而利培酮治疗后首发 SZ 患者载脂蛋白 A1（ApoA1）普遍升高。

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.