Evaluation of bidirectional gut-brain axis and anorectal function in Parkinson's disease with constipation

Yun Yan, Karunaratne Tennekoon, Audrey Eubanks, Anam Herekar, Dhanush Shimoga, Deepak Ayyala, Colin McLeod, Julie A. Kurek, John C. Morgan, Satish S. C. Rao, Amol Sharma
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Abstract

Parkinson's disease (PD) is a neurodegenerative movement disorder with prodromal and highly prevalent gastrointestinal (GI) symptoms, especially constipation. Although PD models suggest gut-brain axis dysfunction, the mechanistic underpinnings and their correlation with GI symptoms are poorly understood.

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评估伴有便秘的帕金森病患者的双向肠脑轴和肛门直肠功能
帕金森病(Parkinson's disease,PD)是一种神经退行性运动障碍疾病,具有前驱症状和高发胃肠道(GI)症状,尤其是便秘。虽然帕金森病模型表明肠脑轴功能紊乱,但人们对其机理基础及其与胃肠道症状的相关性知之甚少。
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