Artificial viruses: A nanotechnology based approach

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY DARU Journal of Pharmaceutical Sciences Pub Date : 2023-12-18 DOI:10.1007/s40199-023-00496-6
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Abstract

Objectives

The main objective of this work was to review and summarise the detailed literature available on viral nanoparticle and the strategies utilised for their manufacture along with their applications as therapeutic agents.

Data acquisition

The reported literature related to development and application of virus nanoparticles have been collected from electronic data bases like ScienceDirect, google scholar, PubMed by using key words like “viral nanoparticles”, “targeted drug delivery” and “vaccines” and related combinations.

Result

From the detailed literature survey, virus nanoparticles were identified as carriers for the targeted delivery. Due to the presence of nanostructures in virus nanoparticles, these protect the drugs from the degradation in the gastrointestinal tract and in case of the delivery of gene medicine, they carry the nucleic acids to the target/susceptible host cells. Thus, artificial viruses are utilised for targeted delivery to specific organ in biomedical and biotechnological areas.

Conclusion

Thus, virus nanoparticles can be considered as viable option as drug/gene carrier in various healthcare sectors especially drug delivery and vaccine and can be explored further in future for the development of better drug delivery techniques.

Graphical Abstract

Abstract Image

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人造病毒:基于纳米技术的方法
摘要 目的 这项工作的主要目的是回顾和总结有关病毒纳米粒子的详细文献、制造策略及其作为治疗剂的应用。 数据采集 通过使用 "病毒纳米粒子"、"靶向给药 "和 "疫苗 "等关键词及相关组合,从 ScienceDirect、google scholar 和 PubMed 等电子数据库中收集了与病毒纳米粒子的开发和应用相关的文献。 结果 通过详细的文献调查,确定病毒纳米粒子为靶向给药的载体。由于病毒纳米粒子中存在纳米结构,这些结构可保护药物在胃肠道中不被降解,在输送基因药物时,病毒纳米粒子可将核酸输送到目标/易感宿主细胞中。因此,在生物医学和生物技术领域,人造病毒被用于定向输送到特定器官。 结论 因此,病毒纳米粒子可被视为各种医疗保健领域(尤其是药物输送和疫苗领域)药物/基因载体的可行选择,未来可进一步探索开发更好的药物输送技术。 图表摘要
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来源期刊
DARU Journal of Pharmaceutical Sciences
DARU Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-
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期刊介绍: DARU Journal of Pharmaceutical Sciences is a peer-reviewed journal published on behalf of Tehran University of Medical Sciences. The journal encompasses all fields of the pharmaceutical sciences and presents timely research on all areas of drug conception, design, manufacture, classification and assessment. The term DARU is derived from the Persian name meaning drug or medicine. This journal is a unique platform to improve the knowledge of researchers and scientists by publishing novel articles including basic and clinical investigations from members of the global scientific community in the forms of original articles, systematic or narrative reviews, meta-analyses, letters, and short communications.
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