The Multivariate Generalized Linear Hawkes Process in High Dimensions with Applications in Neuroscience

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-12-19 DOI:10.1007/s11009-023-10063-w
Masoumeh Fallahi, Reza Pourtaheri, Farzad Eskandari
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Abstract

The Hawkes process models have been recently become a popular tool for modeling and analysis of neural spike trains. In this article, motivated by neuronal spike trains study, we propose a novel multivariate generalized linear Hawkes process model, where covariates are included in the intensity function. We consider the problem of simultaneous variable selection and estimation for the multivariate generalized linear Hawkes process in the high-dimensional regime. Estimation of the intensity function of the high-dimensional point process is considered within a nonparametric framework, applying B-splines and the SCAD penalty for matters of sparsity. We apply the Doob-Kolmogorov inequality and the martingale central limit theory to establish the consistency and asymptotic normality of the resulting estimators. Finally, we illustrate the performance of our proposal through simulation and demonstrate its utility by applying it to the neuron spike train data set.

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高维度多变量广义线性霍克斯过程及其在神经科学中的应用
霍克斯过程模型近来已成为神经尖峰列车建模和分析的常用工具。本文从神经元尖峰列车研究出发,提出了一种新的多元广义线性霍克斯过程模型,该模型的强度函数中包含协变量。我们考虑了高维条件下多元广义线性霍克斯过程的同步变量选择和估计问题。我们在非参数框架内考虑了高维点过程强度函数的估计问题,在稀疏性问题上应用了 B 样条和 SCAD 惩罚。我们应用 Doob-Kolmogorov 不等式和马氏中心极限理论来确定所得估计值的一致性和渐近正态性。最后,我们通过仿真说明了我们建议的性能,并通过将其应用于神经元尖峰训练数据集来证明其实用性。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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