Brief Report: Nonmalignant Surgical Resection Among Individuals with Screening-Detected Versus Incidental Lung Nodules

IF 3.3 3区医学 Q2 ONCOLOGY Clinical lung cancer Pub Date : 2024-05-01 DOI:10.1016/j.cllc.2023.12.006

Brian M. Till , Tyler Grenda , Taylor Tidwell , Baylor Wickes , Christine Shusted , Brooke Ruane , Olugbenga Okusanya , Nathaniel R. Evans III , Julie A. Barta

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Abstract

•
With the increasing emphasis on early detection of lung cancer through lung cancer screening programs and incidental lung nodule programs, identifying and measuring clinically relevant patient-centered outcomes is critical.
•
This study aimed to characterize factors associated with nonmalignant surgical resection among patients with suspicious pulmonary nodules, focusing on comparisons among individuals with screen-detected versus incidental lung nodules. Individuals with screen-detected or incidental lung nodules may experience differing nodule management strategies and surgical outcomes.
•
In addition, receipt of more intensive lung nodule management may be associated with lower odds of nonmalignant resection. These findings underscore the need for further investigation of best practices in lung nodule management by multidisciplinary teams.

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简要报告：筛查发现的肺结节与偶发肺结节患者的非恶性切除术：肺结节管理的差异

背景：目前，通过肺癌筛查 (LCS) 计划发现肺结节的患者与偶然发现肺结节的患者是否会因为其结节检测状态而经历不同的临床和手术结果，这一点仍不得而知。我们旨在描述基线特征、肺结节评估策略和非恶性切除（NMR）率，重点比较筛查发现的肺结节与偶然发现的肺结节之间的差异。方法我们对 2018 年 1 月至 2021 年 8 月期间在一家机构接受筛查发现或偶然发现的肺结节疑似肺癌手术切除的患者进行了回顾性分析。使用 SPSS 进行了统计分析，包括卡方检验、独立 t 检验和逻辑回归分析。结果在接受手术切除的 256 例患者中，228 例（89.1%）为偶然发现的结节，28 例（10.9%）为筛查发现的结节。与偶然发现结节组相比，筛查发现结节组的黑人患者比例更高，吸烟史更长。这组患者的核磁共振成像率也较高，但无统计学意义。与偶然发现肺部结节的患者相比，筛查发现结节的患者接受指南一致或更强化肺部结节管理的比例明显更高。单变量分析显示，年龄、结节直径、PET SUV-最大值和结节管理策略与 NMR 相关。结论筛查出肺部结节和偶然发现肺部结节的患者可能会经历不同的结节管理策略和手术结果。应继续在早期检测项目中研究导致以患者为中心的结果的人口学、临床和其他因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical lung cancer 医学-肿瘤学

CiteScore

7.00

自引率

2.80%

发文量

159

审稿时长

24 days

期刊介绍： Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.