{"title":"How much schizophrenia do famines cause?","authors":"Cormac Ó Gráda, Chihua Li, L. H. Lumey","doi":"10.1038/s41537-023-00416-2","DOIUrl":null,"url":null,"abstract":"<p>Since the 1970s, famines have been widely invoked as natural experiments in research into the long-term impact of foetal exposure to nutritional shocks. That research has produced compelling evidence for a robust link between foetal exposure and the odds of developing schizophrenia. However, the implications of that research for the human cost of famines in the longer run have not been investigated. We address the connection between foetal origins and schizophrenia with that question in mind. The impact turns out to be very modest—much less than one per cent of the associated famine death tolls—across a selection of case studies.</p>","PeriodicalId":19328,"journal":{"name":"NPJ Schizophrenia","volume":"35 1","pages":""},"PeriodicalIF":5.7000,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ Schizophrenia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41537-023-00416-2","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Since the 1970s, famines have been widely invoked as natural experiments in research into the long-term impact of foetal exposure to nutritional shocks. That research has produced compelling evidence for a robust link between foetal exposure and the odds of developing schizophrenia. However, the implications of that research for the human cost of famines in the longer run have not been investigated. We address the connection between foetal origins and schizophrenia with that question in mind. The impact turns out to be very modest—much less than one per cent of the associated famine death tolls—across a selection of case studies.
期刊介绍:
npj Schizophrenia is an international, peer-reviewed journal that aims to publish high-quality original papers and review articles relevant to all aspects of schizophrenia and psychosis, from molecular and basic research through environmental or social research, to translational and treatment-related topics. npj Schizophrenia publishes papers on the broad psychosis spectrum including affective psychosis, bipolar disorder, the at-risk mental state, psychotic symptoms, and overlap between psychotic and other disorders.