The effects of auditory deprivation on morphological maturation of the ventral cochlear nucleus.

M Anniko, B Sjöström, D Webster
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引用次数: 7

Abstract

The volumes of the auditory brainstem nuclei and age-related auditory brainstem response (ABR) thresholds were analyzed in homozygote (je/je) and heterozygote (je/+) jerker mutant mice. Altogether 97 mice were used in the study. Je/je mice never develop any hearing. The dorsal (DCN) and ventral (VCN) cochlear nuclei were found to have stopped their growth at 56 days after birth. In je/+ mutants, ABR thresholds remained normal or near-normal for 3-6 months, whereas VCN and DCN volumes remained unchanged at least after 56 days after birth. There is no significant difference in DCN volume in je/je and je/+ mice. However, the VCN volume and the cross-sectional area of globular cells were both significantly larger in je/+ than in je/je mice (P less than 0.01). These findings show that auditory deprivation during the maturation of hearing in je/je mutants causes an incomplete maturation of only the ventral cochlear nucleus.

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听觉剥夺对耳蜗腹侧核形态成熟的影响。
分析纯合子(je/je)和杂合子(je/+)突变小鼠听脑干核体积和年龄相关的听脑干反应(ABR)阈值。该研究共使用了97只小鼠。乙脑/乙脑小鼠从未发育出任何听觉。出生后56天,耳蜗背核(DCN)和腹核(VCN)停止生长。在乙脑/+突变体中,ABR阈值在3-6个月内保持正常或接近正常,而VCN和DCN容量至少在出生后56天后保持不变。乙脑/乙脑和乙脑/阳性小鼠的DCN体积无显著差异。而乙脑/乙脑+组的VCN体积和球状细胞横截面积均显著大于乙脑/乙脑小鼠(P < 0.01)。这些发现表明,在乙脑/乙脑突变体的听力成熟过程中,听觉剥夺导致仅腹侧耳蜗核不完全成熟。
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