Current views on in vivo models for breast cancer research and related drug development.

IF 6 2区 医学 Q1 PHARMACOLOGY & PHARMACY Expert Opinion on Drug Discovery Pub Date : 2024-02-01 DOI:10.1080/17460441.2023.2293152
Tiago Ferreira, Tiago Azevedo, Jessica Silva, Ana I Faustino-Rocha, Paula A Oliveira
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Abstract

Introduction: Animal models play a crucial role in breast cancer research, in particular mice and rats, who develop mammary tumors that closely resemble their human counterparts. These models allow the study of mechanisms behind breast carcinogenesis, as well as the efficacy and safety of new, and potentially more effective and advantageous therapeutic approaches. Understanding the advantages and disadvantages of each model is crucial to select the most appropriate one for the research purpose.

Area covered: This review provides a concise overview of the animal models available for breast cancer research, discussing the advantages and disadvantages of each one for searching new and more effective approaches to treatments for this type of cancer.

Expert opinion: Rodent models provide valuable information on the genetic alterations of the disease, the tumor microenvironment, and allow the evaluation of the efficacy of chemotherapeutic agents. However, in vivo models have limitations, and one of them is the fact that they do not fully mimic human diseases. Choosing the most suitable model for the study purpose is crucial for the development of new therapeutic agents that provide better care for breast cancer patients.

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关于乳腺癌研究和相关药物开发的体内模型的当前观点。
导言:动物模型在乳腺癌研究中发挥着至关重要的作用,尤其是小鼠和大鼠,它们所患的乳腺肿瘤与人类的乳腺肿瘤非常相似。通过这些模型可以研究乳腺癌发生的机制,以及新的和可能更有效、更有利的治疗方法的有效性和安全性。了解每种模型的优缺点对于选择最适合研究目的的模型至关重要:本综述简明扼要地概述了可用于乳腺癌研究的动物模型,讨论了每种动物模型在寻找新的、更有效的乳腺癌治疗方法方面的优缺点:啮齿类动物模型提供了有关疾病遗传改变和肿瘤微环境的宝贵信息,并允许对化疗药物的疗效进行评估。然而,体内模型也有局限性,其中之一就是不能完全模拟人类疾病。选择最适合研究目的的模型对于开发新的治疗药物,为乳腺癌患者提供更好的治疗至关重要。
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来源期刊
CiteScore
10.20
自引率
1.60%
发文量
78
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Drug Discovery (ISSN 1746-0441 [print], 1746-045X [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on novel technologies involved in the drug discovery process, leading to new leads and reduced attrition rates. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering chemoinformatics; bioinformatics; assay development; novel screening technologies; in vitro/in vivo models; structure-based drug design; systems biology Drug Case Histories examining the steps involved in the preclinical and clinical development of a particular drug The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and other closely related professionals looking to enhance the success of their drug candidates through optimisation at the preclinical level.
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