In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan.

IF 1.4 Q3 ANATOMY & MORPHOLOGY Anatomy & Cell Biology Pub Date : 2024-03-31 Epub Date: 2023-12-11 DOI:10.5115/acb.23.219
Mehrdad Ghorbanlou, Fatemeh Moradi, Mohammad Hassan Kazemi-Galougahi, Maasoume Abdollahi
{"title":"In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan.","authors":"Mehrdad Ghorbanlou, Fatemeh Moradi, Mohammad Hassan Kazemi-Galougahi, Maasoume Abdollahi","doi":"10.5115/acb.23.219","DOIUrl":null,"url":null,"abstract":"<p><p>Morphologic changes in the brain through aging, as a physiologic process, may involve a wide range of variables including ventricular dilation, and sulcus widening. This study reports normal ranges of these changes as standard criteria. Normal brain computed tomography scans of 400 patients (200 males, 200 females) in every decade of life (20 groups each containing 20 participants) were investigated for subcortical/cortical atrophy (bicaudate width [BCW], third ventricle width [ThVW], maximum length of lateral ventricle at cella media [MLCM], bicaudate index [BCI], third ventricle index [ThVI], and cella media index 3 [CMI3], interhemispheric sulcus width [IHSW], right hemisphere sulci diameter [RHSD], and left hemisphere sulci diameter [LHSD]), ventricular symmetry. Distribution and correlation of all the variables were demonstrated with age and a multiple linear regression model was reported for age prediction. Among the various parameters of subcortical atrophy, BCW, ThVW, MLCM, and the corresponding indices of BCI, ThVI, and CMI3 demonstrated a significant correlation with age (R<sup>2</sup>≥0.62). All the cortical atrophy parameters including IHSW, RHSD, and LHSD demonstrated a significant correlation with age (R<sup>2</sup>≥0.63). This study is a thorough investigation of variables in a normal brain which can be affected by aging disclosing normal ranges of variables including major ventricular variables, derived ventricular indices, lateral ventricles asymmetry, cortical atrophy, in every decade of life introducing BW, ThVW, MLCM, BCI, ThVI, CMI3 as most significant ventricular parameters, and IHSW, RHSD, LHSD as significant cortical parameters associated with age.</p>","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10968186/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anatomy & Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5115/acb.23.219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Morphologic changes in the brain through aging, as a physiologic process, may involve a wide range of variables including ventricular dilation, and sulcus widening. This study reports normal ranges of these changes as standard criteria. Normal brain computed tomography scans of 400 patients (200 males, 200 females) in every decade of life (20 groups each containing 20 participants) were investigated for subcortical/cortical atrophy (bicaudate width [BCW], third ventricle width [ThVW], maximum length of lateral ventricle at cella media [MLCM], bicaudate index [BCI], third ventricle index [ThVI], and cella media index 3 [CMI3], interhemispheric sulcus width [IHSW], right hemisphere sulci diameter [RHSD], and left hemisphere sulci diameter [LHSD]), ventricular symmetry. Distribution and correlation of all the variables were demonstrated with age and a multiple linear regression model was reported for age prediction. Among the various parameters of subcortical atrophy, BCW, ThVW, MLCM, and the corresponding indices of BCI, ThVI, and CMI3 demonstrated a significant correlation with age (R2≥0.62). All the cortical atrophy parameters including IHSW, RHSD, and LHSD demonstrated a significant correlation with age (R2≥0.63). This study is a thorough investigation of variables in a normal brain which can be affected by aging disclosing normal ranges of variables including major ventricular variables, derived ventricular indices, lateral ventricles asymmetry, cortical atrophy, in every decade of life introducing BW, ThVW, MLCM, BCI, ThVI, CMI3 as most significant ventricular parameters, and IHSW, RHSD, LHSD as significant cortical parameters associated with age.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
寻找正常大脑在衰老过程中皮层下和皮层形态的变化:计算机断层扫描研究。
作为一个生理过程,大脑在衰老过程中的形态变化可能涉及多种变量,包括脑室扩张和脑沟增宽。本研究以这些变化的正常范围作为标准。研究人员对 400 名患者(200 名男性,200 名女性)每十年的正常脑部计算机断层扫描结果(20 组,每组 20 人)进行了皮层下/皮层萎缩(云母状宽度 [BCW]、第三脑室宽度 [ThVW]、侧脑室宽度 [ThVW])的调查、MLCM]、双核指数[BCI]、第三脑室指数[ThVI]和第三脑室指数[CMI3]、半球间沟宽度[IHSW]、右半球沟直径[RHSD]和左半球沟直径[LHSD])、脑室对称性。所有变量的分布和相关性均与年龄有关,并报告了一个预测年龄的多元线性回归模型。在皮层下萎缩的各种参数中,BCW、ThVW、MLCM 以及 BCI、ThVI 和 CMI3 的相应指数与年龄有显著相关性(R2≥0.62)。包括 IHSW、RHSD 和 LHSD 在内的所有皮质萎缩参数均与年龄有显著相关性(R2≥0.63)。这项研究对正常大脑中可能受衰老影响的变量进行了深入调查,揭示了生命每十年中主要脑室变量、衍生脑室指数、侧脑室不对称性、皮质萎缩等变量的正常范围,将体重、ThVW、MLCM、BCI、ThVI、CMI3 作为最重要的脑室参数,将 IHSW、RHSD、LHSD 作为与年龄相关的重要皮质参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Anatomy & Cell Biology
Anatomy & Cell Biology ANATOMY & MORPHOLOGY-
CiteScore
1.80
自引率
9.10%
发文量
75
期刊最新文献
Cost-effectiveness and other considerations for different research techniques applied in ancient DNA analysis. Histological features of the Purkinje neurons of the Albino rat (Rattus norvegicus) following letrozole administration. Anatomical and morphometric features of the profunda brachii artery. A new metric method for sex estimation using three-dimensional imaging of the nuchal crest. Profiles, tissue and microbial integrity of cadavers used in medical faculties in South-western Uganda: implication in anatomical education.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1