Potential Role of Zinc Finger 365 rs10822013 and rs10995190 in Mammographic Density, Sporadic Breast Cancer Risk, and Prognosis.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2023-11-01 DOI:10.30476/IJMS.2023.96141.2767
Seyed Reza Ghadamgahi, Leila Hosseinzadeh, Sahar Ardalan Khales, Mohammadreza Nassiri, Maryam Alidoust, Shirin Etemadrezaei, Asma Khorshid Shamshiri, Fatemeh Homaei Shandiz, Alireza Pasdar, Fahimeh Afzaljavan
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Abstract

Background: Despite suggesting many genetic risk markers as the outcome of Genome-wide association studies (GWAS) for breast cancer, replicating the results in different populations has remained the main issue. In this regard, this study assessed the association of two variations in Zinc Finger 365 (ZNF365) in an Iranian population.

Methods: In a case-control study conducted at Mashhad University of Medical Sciences, Mashhad, Iran, between 2017 and 2020, ZNF365-rs10822013 and rs10995190 were genotyped using Allele-Specific PCR (AS-PCR). Breast density was assessed using mammography images. PHASE software module version 2 and SPSS version 16.0 were used for haplotype and statistical analyses. Quantitative and qualitative variables were compared between groups using independent t tests and Chi square tests, respectively. Binary logistic regression analysis was performed to calculate odds ratios. Multivariate analysis was then undertaken for the baseline variables, with a P<0.05 in the univariate analysis. The survival analysis was performed using the Kaplan-Meier method and the log-rank test.

Results: In this survey, 732 females, including 342 breast cancer patients and 390 healthy subjects, were enrolled. rs10822013-T allele (P=0.014), rs10995190-G allele (P=0.003), and TG haplotype (P=0.002) were significantly associated with the increased risk of breast cancer. Moreover, rs10995190-GG genotype (P=0.042) and C-G haplotype (P=0.019) revealed a significant association with better overall survival. However, considered polymorphisms and their haplotypes indicated no association with breast density and clinical features of breast cancer.

Conclusion: ZNF365 variants might be a potential risk marker of breast cancer in the Iranian population. The interaction between alleles in haplotypes may modulate the amount of the risk conferred by these variants. Further studies on different ethnic groups can validate these results.

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锌指365 rs10822013 和 rs10995190 在乳腺密度、散发性乳腺癌风险和预后中的潜在作用。
背景:尽管乳腺癌全基因组关联研究(GWAS)提出了许多遗传风险标记,但在不同人群中复制研究结果仍是一个主要问题。为此,本研究评估了伊朗人群中锌指 365(ZNF365)的两个变异的关联性:在伊朗马什哈德市马什哈德医科大学于 2017 年至 2020 年进行的一项病例对照研究中,使用等位基因特异性 PCR(AS-PCR)对 ZNF365-rs10822013 和 rs10995190 进行了基因分型。乳房密度使用乳房 X 射线摄影图像进行评估。使用 PHASE 软件模块 2 版和 SPSS 16.0 版进行单倍型和统计分析。组间定量和定性变量的比较分别采用独立 t 检验和卡方检验。二元逻辑回归分析用于计算几率比。然后对基线变量进行多变量分析,得出结果:rs10822013-T等位基因(P=0.014)、rs10995190-G等位基因(P=0.003)和TG单倍型(P=0.002)与乳腺癌风险增加显著相关。此外,rs10995190-GG 基因型(P=0.042)和 C-G 单倍型(P=0.019)与较好的总生存率也有明显关系。然而,考虑的多态性及其单倍型与乳腺密度和乳腺癌的临床特征没有关联:ZNF365变异可能是伊朗人患乳腺癌的潜在风险标志物。单倍型中等位基因之间的相互作用可能会调节这些变异所带来的风险。对不同种族群体的进一步研究可以验证这些结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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