Morin hydrate downregulates inflammation-mediated nitric oxide overproduction and potentiates antioxidant mechanism against anticancer drug doxorubicin oxidative hepatorenal toxicity in rats.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-09-01 DOI:10.22038/AJP.2023.22392

Ademola C Famurewa, Chima A Ekeleme-Egedigwe, Patience N Ogbu, Ayodeji J Ajibare, Moshood A Folawiyo, Doris O Obasi, Arunaksharan Narayanankutty

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Abstract

Objective: Doxorubicin (DOX) is a frontline antineoplastic drug that kills cancer cells through genotoxic mechanism; however, it induces organ toxicities. This study assayed whether morin hydrate (MOH) could abrogate DOX hepatorenal toxicity in rats.

Materials and methods: There were 4 groups of rats: Control, MOH, DOX and MOH + DOX. Rats were administered MOH (orally, 100 mg/kg bw) for 7 consecutive days, while DOX was injected (40 mg/kg, ip) on the 5th day only. Hepatorenal function markers, and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were estimated in both organs. Hepatorenal glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) levels were estimated with histopathology.

Results: DOX significantly (p<0.05) reduced antioxidant enzyme activities and GSH level, while NO and MDA levels increased (p<0.05) compared to the control. DOX prominently altered hepatorenal indices and induced histopathological alterations. MOH abrogated the DOX hepatorenal toxicity and alleviated the histological lesions in the liver and kidney.

Conclusion: MOH restored the indices via antioxidant mechanism and downregulation of NO overproduction in rats.

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水合吗啉能降低炎症介导的一氧化氮过量产生，并增强抗氧化机制，防止抗癌药物多柔比星对大鼠肝肾的氧化毒性。

目的：多柔比星（DOX）是通过基因毒性机制杀死癌细胞的一线抗肿瘤药物，但它也会引起器官毒性。本研究探讨了水合吗啉（MOH）能否减轻 DOX 对大鼠肝肾的毒性：材料和方法：大鼠共 4 组：对照组、MOH 组、DOX 组和 MOH + DOX 组。大鼠连续 7 天口服 MOH（100 毫克/千克体重），仅在第 5 天注射 DOX（40 毫克/千克，ip）。对两个器官的肝肾功能指标、谷胱甘肽过氧化物酶（GPx）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性进行了评估。通过组织病理学评估肝脏谷胱甘肽（GSH）、丙二醛（MDA）和一氧化氮（NO）的水平：结果：DOX明显（pMOH通过抗氧化机制和下调一氧化氮的过量产生，恢复了大鼠的各项指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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