The alterations of cardiac function during venovenous artificial placenta support in fetal goats.

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL International Journal of Artificial Organs Pub Date : 2024-01-01 Epub Date: 2023-12-19 DOI:10.1177/03913988231215905

Guanhua Li, Mingliang Li, Yun Teng, Li Zhang, Chengcheng Pang, Jianfeng Tan, Jimei Chen, Jian Zhuang, Chengbin Zhou

{"title":"The alterations of cardiac function during venovenous artificial placenta support in fetal goats.","authors":"Guanhua Li, Mingliang Li, Yun Teng, Li Zhang, Chengcheng Pang, Jianfeng Tan, Jimei Chen, Jian Zhuang, Chengbin Zhou","doi":"10.1177/03913988231215905","DOIUrl":null,"url":null,"abstract":"Introduction: Venovenous artificial placenta (VVAP) may mimic the intrauterine environment for maintaining fetal circulation. However, changes in ventricular function in fetal goats undergoing VVAP support remain unclear.Methods: Pump-assisted VVAPs were established in five fetal goats for 9 h. The myocardial performance index (Tei index), cardiac output (CO), and blood biochemical parameters were measured during VVAP support.Results: An increasing trend of the right ventricular (RV) Tei index was seen during VVAP support (p for trend < 0.01). The right ventricular cardiac output (RVCO) increased after the initiation of VVAP, while a significant trend of reduction was observed after 3 h (p for trend = 0.03). During VVAP support, we observed remarkable elevations of plasma cTnI and arterial lactic acid, which were positively correlated with the RV Tei index, but not the left ventricular (LV) Tei index, LVCO, and RVCO.Conclusions: The RVCO increases initially while a tendency of decrease could be observed during VVAP support. Special attention should be paid to right ventricular dysfunction during VVAP support.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"17-24"},"PeriodicalIF":1.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Artificial Organs","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/03913988231215905","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/19 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Venovenous artificial placenta (VVAP) may mimic the intrauterine environment for maintaining fetal circulation. However, changes in ventricular function in fetal goats undergoing VVAP support remain unclear.

Methods: Pump-assisted VVAPs were established in five fetal goats for 9 h. The myocardial performance index (Tei index), cardiac output (CO), and blood biochemical parameters were measured during VVAP support.

Results: An increasing trend of the right ventricular (RV) Tei index was seen during VVAP support (p for trend < 0.01). The right ventricular cardiac output (RVCO) increased after the initiation of VVAP, while a significant trend of reduction was observed after 3 h (p for trend = 0.03). During VVAP support, we observed remarkable elevations of plasma cTnI and arterial lactic acid, which were positively correlated with the RV Tei index, but not the left ventricular (LV) Tei index, LVCO, and RVCO.

Conclusions: The RVCO increases initially while a tendency of decrease could be observed during VVAP support. Special attention should be paid to right ventricular dysfunction during VVAP support.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

胎儿山羊静脉人工胎盘支持过程中心脏功能的改变。

导言：静脉人工胎盘（VVAP）可模拟宫内环境以维持胎儿循环。然而，接受 VVAP 支持的胎儿山羊心室功能的变化仍不清楚：在 VVAP 支持期间测量了心肌性能指数（Tei 指数）、心输出量（CO）和血液生化指标：结果：在 VVAP 支持期间，右心室 Tei 指数呈上升趋势（p for trend p for trend = 0.03）。在 VVAP 支持期间，我们观察到血浆 cTnI 和动脉乳酸显著升高，这与 RV Tei 指数呈正相关，但与左心室 Tei 指数、LVCO 和 RVCO 无关：结论：在 VVAP 支持期间，RVCO 最初会增加，但随后会呈下降趋势。结论：在 VVAP 支持过程中，RVCO 最初会增加，但随后会呈下降趋势。在 VVAP 支持过程中，应特别注意右心室功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

International Journal of Artificial Organs 医学-工程：生物医学

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

3 months

期刊介绍： The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.