Interleukin 28B Polymorphism Predicts Treatment Outcome Among Egyptian Patients Infected With HCV Genotype 4.

Hepato-gastroenterology Pub Date : 2015-06-01

Mahmoud El-Bendary, Mustafa A Neamatallah, Mohamed Abd El-Maksoud, Maha Amin

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Abstract

Background/aims: Egypt has the highest prevalence of HCV worldwide (15%) with a high morbidity and mortality from chronic liver disease, cirrhosis, and hepatocellular carcinoma. The Aim of this study was to investigate the associations between IL-28B single nucleotide polymorphisms (SNP rs12979860) and treatment outcome among Egyptian patients infected with HCV genotype 4.

Methodology: HCV patients were genotyped as CC, CT, or TT at the polymorphic site, rs12979860 in unrelated case control of Egyptian population with HCV.

Results: By using univariate regression analysis, the minor allele of IL28B (p < 0.0001), high serum level of HCV-RNA (p = 0.035), and advanced fibrosis (p = 0.02) were associated with (NRs) (Odds ratio, 3.75 with 95% confidence nterval (2.308-6.1067). While, in multivariate logistic regression analysis, rs12979860 CC genotype was the strongest predictive of SVR (OR = 20.83, 95% CI = 11.63- 37.04, p < 0.0001).

Conclusion: The IL28B rs12979860 SNP is the strongest predictor of an SVR among Egyptian patients infected with HCV-4.

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白细胞介素 28B 多态性可预测感染了 HCV 基因型 4 的埃及患者的治疗效果。

背景/目的：埃及是全球丙型肝炎病毒感染率最高的国家（15%），慢性肝病、肝硬化和肝细胞癌的发病率和死亡率都很高。本研究的目的是调查 IL-28B 单核苷酸多态性（SNP rs12979860）与感染 HCV 基因型 4 的埃及患者的治疗效果之间的关系。方法：在感染 HCV 的埃及非相关病例对照人群中，将 HCV 患者的多态性位点 rs12979860 的基因分型为 CC、CT 或 TT：通过单变量回归分析，IL28B 的小等位基因（p < 0.0001）、高血清 HCV-RNA 水平（p = 0.035）和晚期纤维化（p = 0.02）与（NRs）相关（Odds ratio，3.75，95% 置信区间（2.308-6.1067））。而在多变量逻辑回归分析中，rs12979860 CC 基因型对 SVR 的预测作用最强（OR = 20.83，95% CI = 11.63- 37.04，p < 0.0001）：IL28B rs12979860 SNP是埃及HCV-4感染者获得SVR的最强预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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