Characteristics of patients with psoriatic arthritis in Korea: focusing on axial involvement.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Korean Journal of Internal Medicine Pub Date : 2024-01-01 Epub Date: 2023-12-08 DOI:10.3904/kjim.2023.044

Hanna Park, Ji Hyun Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park, Jennifer Jooha Lee

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Abstract

Background/aims: We aimed to clarify the clinical characteristics of psoriatic arthritis (PsA) in Korean patients focusing on PsA with axial involvement.

Methods: A retrospective medical chart review was performed to identify PsA patients at a single tertiary center. Cases of AS patients with psoriasis were recruited from a prospective AS registry of the same center. Demographics, laboratory findings, and radiologic characteristics were assessed.

Results: A total of 69 PsA patients were identified. In PsA patients, spondylitis (46.4%) was the most common form. Compared to AS patients with psoriasis, PsA patients with radiographic axial involvement were older (50.9 vs. 32.4 years; p < 0.001) and showed greater peripheral disease activity (peripheral arthritis 78.1 vs. 12.5%, p < 0.001; enthesitis 50.0 vs. 6.3%, p = 0.003). AS patients with psoriasis presented a higher rate of HLA-B*27 positivity (81.3 vs. 17.2%; p < 0.001) and a more frequent history of inflammatory back pain (100.0 vs. 75.0%; p = 0.039) than PsA patients with radiographic axial involvement. Significant proportions of PsA patients with radiographic axial involvement had cervical spine involvement (10/18, 55.6%) and spondylitis without sacroiliitis (10/23, 43.5%).

Conclusion: We demonstrate that axial involvement is common in Korean PsA patients, and its characteristics can be distinct from those of AS.

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韩国银屑病关节炎患者的特征：重点关注轴向受累。

背景/目的我们旨在明确韩国患者银屑病关节炎（PsA）的临床特征，重点关注有轴向受累的PsA：方法：我们对病历进行了回顾性分析，以确定一家三级医疗中心的 PsA 患者。从同一中心的前瞻性强直性脊柱炎登记处招募了伴有银屑病的强直性脊柱炎患者病例。对人口统计学、实验室检查结果和放射学特征进行了评估：结果：共发现 69 例 PsA 患者。在PsA患者中，脊柱炎（46.4%）是最常见的类型。与伴有银屑病的AS患者相比，有放射学轴向受累的PsA患者年龄更大（50.9岁对32.4岁，P＜0.001），外周疾病活动度更大（外周关节炎78.1%对12.5%，P＜0.001；关节内膜炎50.0%对6.3%，P=0.003）。与影像学轴向受累的PsA患者相比，银屑病AS患者的HLA-B*27阳性率更高（81.3% vs. 17.2%；p < 0.001），炎性背痛病史更频繁（100.0% vs. 75.0%；p = 0.039）。在影像学上有轴向受累的PsA患者中，颈椎受累（10/18，55.6%）和无骶髂关节炎的脊柱炎（10/23，43.5%）的比例很高：我们的研究表明，轴向受累在韩国PsA患者中很常见，而且其特征与AS的特征截然不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

5.10

自引率

4.20%

发文量

129

审稿时长

20 weeks

期刊介绍： The Korean Journal of Internal Medicine is an international medical journal published in English by the Korean Association of Internal Medicine. The Journal publishes peer-reviewed original articles, reviews, and editorials on all aspects of medicine, including clinical investigations and basic research. Both human and experimental animal studies are welcome, as are new findings on the epidemiology, pathogenesis, diagnosis, and treatment of diseases. Case reports will be published only in exceptional circumstances, when they illustrate a rare occurrence of clinical importance. Letters to the editor are encouraged for specific comments on published articles and general viewpoints.