RNA m6A modifications regulate crosstalk between tumor metabolism and immunity.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2024-01-01 Epub Date: 2023-12-19 DOI:10.1002/wrna.1829
Jinghua Gu, Huake Cao, Xiaoli Chen, Xu Dong Zhang, Rick F Thorne, Xiaoying Liu
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Abstract

In recent years, m6A modifications in RNA transcripts have arisen as a hot topic in cancer research. Indeed, a number of independent studies have elaborated that the m6A modification impacts the behavior of tumor cells and tumor-infiltrating immune cells, altering tumor cell metabolism along with the differentiation and functional activity of immune cells. This review elaborates on the links between RNA m6A modifications, tumor cell metabolism, and immune cell behavior, discussing this topic from the viewpoint of reciprocal regulation through "RNA m6A-tumor cell metabolism-immune cell behavior" and "RNA m6A-immune cell behavior-tumor cell metabolism" axes. In addition, we discuss the various factors affecting RNA m6A modifications in the tumor microenvironment, particularly the effects of hypoxia associated with cancer cell metabolism along with immune cell-secreted cytokines. Our analysis proposes the conclusion that RNA m6A modifications support widespread interactions between tumor metabolism and tumor immunity. With the current viewpoint that long-term cancer control must tackle cancer cell malignant behavior while strengthening anti-tumor immunity, the recognition of RNA m6A modifications as a key factor provides a new direction for the targeted therapy of tumors. This article is categorized under: RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.

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RNA m6A修饰调节肿瘤代谢与免疫之间的相互关系。
近年来,RNA 转录本中的 m6A 修饰已成为癌症研究的热点话题。事实上,许多独立研究已经阐述了 m6A 修饰会影响肿瘤细胞和肿瘤浸润免疫细胞的行为,改变肿瘤细胞的新陈代谢以及免疫细胞的分化和功能活性。本综述阐述了 RNA m6A 修饰、肿瘤细胞代谢和免疫细胞行为之间的联系,从 "RNA m6A-肿瘤细胞代谢-免疫细胞行为 "和 "RNA m6A-免疫细胞行为-肿瘤细胞代谢 "这两个轴相互调控的角度讨论了这一主题。此外,我们还讨论了影响肿瘤微环境中 RNA m6A 修饰的各种因素,特别是与癌细胞代谢相关的缺氧和免疫细胞分泌的细胞因子的影响。我们的分析得出的结论是,RNA m6A修饰支持肿瘤代谢与肿瘤免疫之间的广泛相互作用。目前的观点认为,长期的癌症控制必须在加强抗肿瘤免疫力的同时解决癌细胞的恶性行为,RNA m6A修饰作为一个关键因素的认识为肿瘤的靶向治疗提供了一个新的方向。本文归类于RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease RNA与蛋白质和其他分子的相互作用 > Protein-RNA Interactions:功能影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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