Appropriate patient population for future visual system axon regeneration therapies.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2024-03-01 Epub Date: 2023-12-13 DOI:10.1002/wsbm.1637
Sanjoy K Bhattacharya, Chrisfouad Raif Alabiad, Krishna Kishor
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Abstract

A number of blinding diseases caused by damage to the optic nerve result in progressive vision loss or loss of visual acuity. Secondary glaucoma results from traumatic injuries, pseudoexfoliation or pigmentary dispersion syndrome. Progressive peripheral vision loss is common to all secondary glaucoma irrespective of the initial event. Axon regeneration is a potential therapeutic avenue to restore lost vision in these patients. In contrast to the usual approach of having the worst possible patient population for initial therapies, axon regeneration may require consideration of appropriate patient population even for initial treatment trials. The current state of axon regeneration therapies, their potential future and suitable patient population when ready is discussed in this perspective. The selection of patients are important for adoption of axon regeneration specifically in the areas of central nervous system regenerative medicine. This article is categorized under: Neurological Diseases > Molecular and Cellular Physiology Neurological Diseases > Biomedical Engineering Metabolic Diseases > Molecular and Cellular Physiology.

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未来视觉系统轴突再生疗法的适当患者人群。
许多致盲性疾病都是由于视神经受损而导致视力逐渐减退或丧失。继发性青光眼由外伤、假性角膜剥脱或色素分散综合征引起。继发性青光眼的共同特征是进行性周边视力丧失,而与最初发生的事件无关。轴突再生是恢复这些患者视力的潜在治疗途径。与通常的初始疗法尽可能选择最差的患者人群不同,轴突再生疗法可能需要考虑适当的患者人群,甚至在初始治疗试验中也是如此。本视角将讨论轴突再生疗法的现状、其潜在的未来以及准备就绪后的合适患者人群。患者的选择对于中枢神经系统再生医学领域采用轴突再生疗法非常重要。本文归类于神经系统疾病 > 分子与细胞生理学 神经系统疾病 > 生物医学工程 新陈代谢疾病 > 分子与细胞生理学。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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