{"title":"RHOA drivers take alternate routes in gastric cancer.","authors":"Dorothy Benton, Jonathan Chernoff","doi":"10.1126/scisignal.adk9171","DOIUrl":null,"url":null,"abstract":"<p><p>Oncogenic small guanosine triphosphatases (GTPases) are often characterized by a limited set of activating mutations that affect their intrinsic biochemical function, but RHOA-which is frequently mutated in gastric cancer-appears not to have read the instruction manual. Having previously characterized the Y42C RHOA mutation in gastric cancer, in this issue of <i>Science Signaling</i>, Schaefer <i>et al.</i> take on the slightly less common L57V mutation and find that individual RHOA mutations can have different and unpredictable signaling outcomes.</p>","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":null,"pages":null},"PeriodicalIF":7.3000,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science Signaling","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1126/scisignal.adk9171","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Oncogenic small guanosine triphosphatases (GTPases) are often characterized by a limited set of activating mutations that affect their intrinsic biochemical function, but RHOA-which is frequently mutated in gastric cancer-appears not to have read the instruction manual. Having previously characterized the Y42C RHOA mutation in gastric cancer, in this issue of Science Signaling, Schaefer et al. take on the slightly less common L57V mutation and find that individual RHOA mutations can have different and unpredictable signaling outcomes.
Science SignalingBiochemistry, Genetics and Molecular Biology-Molecular Biology
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148
期刊介绍：
Science Signaling is a weekly, online multidisciplinary journal dedicated to the life sciences. Our editorial team's mission is to publish studies that elucidate the fundamental mechanisms underlying biological processes across various organisms. We prioritize research that offers novel insights into physiology, elucidates aberrant mechanisms leading to disease, identifies potential therapeutic targets and strategies, and characterizes the effects of drugs both in vitro and in vivo.
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