Polymorphisms in PI3K/AKT genes and gene‑smoking interaction are associated with susceptibility to tuberculosis.

IF 1.2 4区医学 Q2 ANTHROPOLOGY Annals of Human Biology Pub Date : 2023-02-01 Epub Date: 2023-12-20 DOI:10.1080/03014460.2023.2288008

Chunli Wu, Huixia Liu, Ying Lin, Rongjing An, Mian Wang, Hua Zhong, Hengzhong Yi, Qiaozhi Wang, Hongzhuan Tan, Lizhang Chen, Jing Deng, Mengshi Chen

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Abstract

Background: Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) are involved in the clearance of Mycobacterium tuberculosis (MTB) by macrophages.

Aim: This study aimed to investigate the effects of polymorphisms in the PI3K/AKT genes and the gene-smoking interaction on susceptibility to TB.

Methods: This case-control study used stratified sampling to randomly select 503 TB patients and 494 control subjects. Logistic regression analysis was used to determine the association between the polymorphisms and TB. Simultaneously, the marginal structure linear dominance model was used to estimate the gene-smoking interaction.

Results: Genotypes GA (OR 1.562), AA (OR 2.282), and GA + AA (OR 1.650) at rs3730089 of the PI3KR1 gene were significantly associated with the risk to develop TB. Genotypes AG (OR 1.460), GG (OR 2.785), and AG + GG (OR 1.622) at rs1130233 of the AKT1 gene were significantly associated with the risk to develop TB. In addition, the relative excess risk of interaction (RERI) between rs3730089 and smoking was 0.9608 (95% CI: 0.5959, 1.3256, p < 0.05), which suggests a positive interaction.

Conclusion: We conclude that rs3730089 and rs1130233 are associated with susceptibility to TB, and there was positive interaction between rs3730089 and smoking on susceptibility to TB.

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PI3K/AKT 基因的多态性和基因与吸烟的相互作用与结核病的易感性有关。

背景：目的：本研究旨在探讨PI3K/AKT基因的多态性以及基因与吸烟的相互作用对结核病易感性的影响：这项病例对照研究采用分层抽样法随机抽取了 503 名肺结核患者和 494 名对照组受试者。采用逻辑回归分析确定多态性与肺结核之间的关联。同时，采用边际结构线性优势模型估计基因与吸烟的交互作用：结果：PI3KR1 基因 rs3730089 的基因型 GA（OR 1.562）、AA（OR 2.282）和 GA + AA（OR 1.650）与肺结核发病风险显著相关。AKT1 基因 rs1130233 的基因型 AG（OR 1.460）、GG（OR 2.785）和 AG + GG（OR 1.622）与结核病发病风险显著相关。此外，rs3730089 与吸烟之间的交互作用相对超额风险（RERI）为 0.9608（95% CI：0.5959，1.3256，p 结论：rs3730089 与吸烟之间的交互作用相对超额风险为 0.9608（95% CI：0.5959，1.3256，p）：我们得出结论：rs3730089 和 rs1130233 与结核病易感性相关，rs3730089 与吸烟对结核病易感性存在正交互作用。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.