Metabolic Blood Hormones in Young People With Electrocardiographic Signs of Ischemic Myocardial Changes.

IF 0.5 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Kardiologiya Pub Date : 2023-12-05 DOI:10.18087/cardio.2023.11.n2492

E M Stakhneva, N A Kuzminykh, L V Scherbakova, E V Kashtanova, Ya V Polonskaya, V S Shramko, E V Garbuzova Striukova, E V Sadovski, Yu I Ragino

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Abstract

Aim To study changes in blood concentrations of metabolic hormones and adipocytokines in people aged 25-44 years with electrocardiographic (ECG) signs of ischemic changes in the myocardium.Material and methods This study was a part of a cross-sectional survey of a random sample of Novosibirsk population aged 25-44 years. The study included 1363 people divided into two groups: group 1, subjects with ECG signs of ischemic changes in the myocardium and group 2, subjects without ECG changes. Blood serum concentrations of adipocytokines and metabolic hormones were measured by multiplex assay on a Luminex MAGPIX flow-through fluorometer.Results The group with ECG signs of myocardial ischemia had higher blood concentrations of adiponectin, resistin, glucagon, and interleukin 6 (IL-6) than in the comparison group. A multivariate logistic regression analysis showed that the glucagon concentration was associated with the presence of ECG signs of myocardial ischemia (OR, 1.019; CI, 1.018-1.034; p=0.017).Conclusion In young people aged 25-44 years, higher blood concentrations of glucagon are associated with the presence of ECG signs of myocardial ischemia.

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有心电图缺血性心肌变化迹象的年轻人血液中的代谢激素

目的研究心电图（ECG）显示心肌缺血变化的 25-44 岁人群血液中代谢激素和脂肪细胞因子浓度的变化。研究对象包括 1363 人，分为两组：第一组为心电图显示心肌缺血变化的受试者，第二组为心电图无变化的受试者。用 Luminex MAGPIX 流式荧光测定仪通过多重测定法测量血清中脂肪细胞因子和代谢激素的浓度。结果有心电图显示心肌缺血症状的受试者血中脂肪连素、抵抗素、胰高血糖素和白细胞介素 6（IL-6）的浓度高于对比组。多变量逻辑回归分析表明，胰高血糖素浓度与心电图显示心肌缺血相关（OR，1.019；CI，1.018-1.034；P=0.017）。

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来源期刊

Kardiologiya 医学-心血管系统

CiteScore

1.70

自引率

20.00%

发文量

审稿时长

3-8 weeks

期刊介绍： “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.