Prospective bidirectional relations between depression and metabolic health: 30-year follow-up from the National Heart, Lung, and Blood Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) study.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-04-01 Epub Date: 2023-12-14 DOI:10.1037/hea0001339

Nicholas R Moorehead, Jeffrey L Goodie, David S Krantz

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Abstract

Objective: This study investigated prospective bidirectional relationships between depressive symptoms and metabolic syndrome (MetS) and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years.

Method: Data were analyzed from the National Heart, Lung, and Blood Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) study, a 30-year prospective study of young adults (N = 5,113; M_age = 24.76 [SD = 3.63] at baseline; 45% male) who were tested every 5 years between 1985 and 2015. Measures included biological assessments of MetS components and self-reported depressive symptoms based on the Center for Epidemiologic Studies Depression (CESD) scale. Data analyses included bidirectional general estimating equations analyses of time-lagged associations between depressive symptoms and MetS.

Results: There was a consistent, bidirectional relationship between depressive symptoms and MetS over time. Individuals with more CESD depressive symptoms were more likely to develop MetS over time compared to those reporting fewer symptoms, Wald χ²(1) = 7.09, p < .008, and MetS was similarly predictive of CESD. MetS more consistently predicted CESD scores at each 5-year exam than CESD predicted MetS. Race and sex moderated these relationships, with White females, White individuals overall, and females overall demonstrating significant relationships between CESD depressive symptoms and MetS. Health behaviors were not related to associations between CESD and MetS.

Conclusion: In a diverse young adult population prospectively followed into late middle age, MetS more consistently predicted depressive symptoms over time than depressive symptoms predicted MetS. The relation between MetS and depressive symptoms was moderated by race and sex, but not health behaviors. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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抑郁与代谢健康之间的前瞻性双向关系：美国国家心肺血液研究所（NHLBI）年轻成年人冠状动脉疾病（CARDIA）研究的 30 年随访。

研究目的本研究调查了一个随访 30 年的多元化队列中抑郁症状与代谢综合征（MetS）之间的前瞻性双向关系，以及种族、性别和健康行为的调节作用：该研究是一项为期30年的前瞻性研究，研究对象为1985年至2015年间每5年接受一次检测的年轻成年人（N = 5,113; Mage = 24.76 [SD = 3.63] at baseline; 45% male）。测量包括 MetS 成分的生物学评估和基于流行病学研究中心抑郁量表 (CESD) 的自我报告抑郁症状。数据分析包括抑郁症状与 MetS 之间时滞关联的双向一般估计方程分析：结果：随着时间的推移，抑郁症状与 MetS 之间存在一致的双向关系。随着时间的推移，CESD 抑郁症状较多的人比症状较少的人更有可能患 MetS，Wald χ²(1) = 7.09，p < .008，而且 MetS 对 CESD 也有类似的预测作用。与 CESD 预测 MetS 相比，MetS 更一致地预测了每次 5 年检查的 CESD 分数。种族和性别调节了这些关系，白人女性、白人个体和女性个体在CESD抑郁症状和MetS之间表现出显著的关系。健康行为与CESD和MetS之间的关系无关：结论：在对进入中年后期的不同年轻成年人群体进行前瞻性跟踪调查后发现，随着时间的推移，MetS 对抑郁症状的预测比抑郁症状对 MetS 的预测更为一致。MetS与抑郁症状之间的关系受种族和性别的影响，但不受健康行为的影响。(PsycInfo Database Record (c) 2023 APA, 版权所有）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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