Management of aggressive variants of papillary thyroid cancer.

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2024-04-01 Epub Date: 2023-11-30 DOI:10.1097/MOO.0000000000000952

Ying Ki Lee, Aleix Rovira, Paul V Carroll, Ricard Simo

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Abstract

Purpose of review: The aim of this study was to provide a timely and relevant review of the latest findings and explore appropriate management of aggressive variants of papillary thyroid cancer (AVPTC).

Recent findings: In general, AVPTCs tend to exhibit more invasive characteristics, a lack of responsiveness to radioiodine, increased occurrences of regional spreading, distant metastases and higher mortality rates. Meanwhile, each variant showcases unique clinical and molecular profiles.

Summary: Given the elevated risk of recurrence postsurgery, a more aggressive strategy may be necessary when suspected preoperatively, particularly for those presenting with invasive features. Decision on the extent of surgical treatment and adjuvant therapy is individualized and made by experienced clinicians and multidisciplinary teams based on the clinical presentation, presence of aggressive features and molecular profile. Future studies on development of personalized medicine and molecular target therapy may offer tailored treatment options.

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甲状腺乳头状癌侵袭性变异的管理。

综述的目的：本研究旨在及时对最新研究结果进行相关综述，并探讨侵袭性变异甲状腺乳头状癌（AVPTC）的适当治疗方法：一般而言，侵袭性变异型甲状腺乳头状癌（AVPTC）往往具有侵袭性更强、对放射性碘缺乏反应性、区域扩散和远处转移发生率更高以及死亡率更高等特点。小结：鉴于术后复发的风险较高，如果术前就怀疑是AVPTC，可能需要采取更积极的策略，尤其是对于那些具有侵袭性特征的患者。手术治疗和辅助治疗的程度需要个体化，由经验丰富的临床医生和多学科团队根据临床表现、侵袭性特征和分子特征来决定。未来的个性化医学和分子靶向治疗研究可能会提供量身定制的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Otolaryngology & Head and Neck Surgery OTORHINOLARYNGOLOGY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Otolaryngology & Head and Neck Surgery is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including maxillofacial surgery, head and neck oncology and speech therapy and rehabilitation – every issue also contains annotated references detailing the merits of the most important papers.

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