Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesis.

Advances in cancer research Pub Date : 2019-01-01 Epub Date: 2019-04-23 DOI:10.1016/bs.acr.2019.03.008
Xuan Mo, Sarah Preston, M Raza Zaidi
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引用次数: 13

Abstract

Cutaneous malignant melanoma is one of the few major cancers that continue to exhibit a positive rate of increase in the developed world. A wealth of epidemiological data has undisputedly implicated ultraviolet radiation (UVR) from sunlight and artificial sources as the major risk factor for melanomagenesis. However, the molecular mechanisms of this cause-and-effect relationship remain murky and understudied. Recent efforts on multiple fronts have brought unprecedented expansion of our knowledge base on this subject and it is now clear that melanoma is caused by a complex interaction between genetic predisposition and environmental exposure, primarily to UVR. Here we provide an overview of the effects of the macroenvironment (UVR) on the skin microenvironment and melanocyte-specific intrinsic (mostly genetic) landscape, which conspire to produce one of the deadliest malignancies.

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紫外线辐射诱导黑色素瘤形成过程中的大环境-基因-微环境相互作用
在发达国家,皮肤恶性黑色素瘤是少数几种继续呈正增长的主要癌症之一。大量流行病学数据无可争辩地表明,来自阳光和人造光源的紫外线辐射(UVR)是导致黑色素瘤的主要风险因素。然而,这种因果关系的分子机制仍然模糊不清,研究也不够深入。最近,我们在多方面做出了努力,使我们在这一问题上的知识库得到了前所未有的扩展,现在已经很清楚,黑色素瘤是由遗传易感性和环境暴露(主要是紫外线)之间复杂的相互作用引起的。在此,我们将概述大环境(紫外线辐射)对皮肤微环境和黑色素细胞特异性内在(主要是遗传)环境的影响,这些因素共同作用,导致黑色素瘤成为最致命的恶性肿瘤之一。
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