Clinical evaluation of antiviral combination treatment in cats with feline herpesvirus-1 infection.

Y Ozkanlar, N Ulas, I Sozdutmaz, S Ozkanlar
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Abstract

Feline herpesvirus-1 (FHV-1) can cause lifelong problems such as rhinotracheitis and ocular disease due to latency and reactivation in affected cats. The particular effects of antiviral drugs have been separately investigated in previous studies for decades and little is known about the combination treatment in active FHV-1 infection. Therefore, we aimed to evaluate the effects of antiviral combination on clinical effectiveness in cats with naturally occurring FHV-1 infection. 28 cats suffering from clinical signs of sneezing, nasal congestion, conjunctivitis, and eye/nose discharge were involved in this study following FHV-1 DNA detection by PCR assay in oculo-oropharyngeal samples. The treatment protocol was as follows: oral famciclovir and L-lysine, ophthalmic acyclovir, and subcutaneous amoxicillin plus clavulanic acid. The symptoms improved each day and total recovery success rate was 80% reduction in clinical scores at the end of the treatment on day 10 (p<0.001). Additionally, PCR was found to be negative for FHV-1 DNA in 82.1% of the samples after the treatment. There were mild decreases in neutrophil and monocyte counts (p>0.05). The arginine to lysine ratio decreased in favour of lysine (p<0.01). As a result, the antiviral combination treatment with famciclovir, L-lysine and ophthalmic acyclovir, and antibacterial drug appears to be clinically effective for the treatment of naturally occurring active FHV-1 infection in cats. In addition, any adverse clinical effect has not been determined associated with the antiviral combination during the study.

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对感染猫疱疹病毒-1 的猫进行抗病毒联合治疗的临床评估。
猫疱疹病毒-1(FHV-1)可导致终身问题,如鼻气管炎和眼部疾病,这是因为受影响的猫有潜伏期和再激活期。数十年来,抗病毒药物的特殊效果一直在以往的研究中被单独研究,而对于活动性 FHV-1 感染的联合治疗却知之甚少。因此,我们旨在评估抗病毒联合疗法对自然发生的 FHV-1 感染猫的临床效果的影响。在通过 PCR 检测眼咽样本中的 FHV-1 DNA 后,28 只患有打喷嚏、鼻塞、结膜炎和眼/鼻分泌物等临床症状的猫参与了本研究。治疗方案如下:口服泛昔洛韦和 L-赖氨酸,眼用阿昔洛韦,皮下注射阿莫西林加克拉维酸。症状每天都有所改善,在治疗结束的第 10 天,临床评分降低了 80%(P0.05)。精氨酸与赖氨酸的比例下降,赖氨酸更有利(P
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