Advances in research on molecular markers in immune checkpoint inhibitor-associated myocarditis

Cancer Innovation Pub Date : 2023-11-28 DOI:10.1002/cai2.100
Jun Shao, Chuanbin Liu, Jing Wang
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Abstract

Immune checkpoint inhibitors (ICIs) play a crucial role in the immunotherapy of malignant tumors, preventing immune evasion by tumor cells and activating autoimmune cells to eliminate the tumor. Despite their proven effectiveness in antitumor therapy, potential immune-related adverse effects must be recognized, particularly ICI-associated myocarditis (ICIAM). ICIAM is the most lethal form of organ immunotoxicity, with a significant impact on short-term mortality. However, ICIAM is predominantly asymptomatic or mildly nonspecific. It is difficult to diagnose, especially due to the lack of unique molecular markers. This article aims to provide a comprehensive overview of the progress made in identifying molecular markers for ICIAM.

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免疫检查点抑制剂相关心肌炎分子标记物研究进展
免疫检查点抑制剂(ICIs)在恶性肿瘤的免疫治疗中发挥着至关重要的作用,它能防止肿瘤细胞逃避免疫,并激活自身免疫细胞以消灭肿瘤。尽管 ICIs 在抗肿瘤治疗中的有效性已得到证实,但必须认识到其潜在的免疫相关不良反应,尤其是 ICI 相关性心肌炎(ICIAM)。ICIAM 是最致命的器官免疫毒性形式,对短期死亡率有重大影响。然而,ICIAM 主要无症状或轻度非特异性。它很难诊断,特别是由于缺乏独特的分子标记物。本文旨在全面概述在确定 ICIAM 分子标记物方面取得的进展。
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