Co(III)-Catalyzed C6-Selective C–H Activation/Pyridine Migration of 2-Pyridones with Propiolates

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2023-12-21 DOI:10.1021/acs.orglett.3c03358

Yue-Lu Zhu*, Na Zhao, Xin-Long Fu, Xin-Yang Zhao, Yan-Lin Li, You-Dong Shao*, Jiao Chen* and Yi Lu,

引用次数: 0

Abstract

A versatile Co(III)-catalyzed C6-selective C–H activation/pyridine migration of 2-pyridones with available propiolates as coupling partners was demonstrated. This method features high atom economy, excellent regioselectivity, and good functional group tolerance by employing an inexpensive Co(III) catalyst under mild reaction conditions. Moreover, gram-scale synthesis and late-stage modifications of pharmaceuticals were performed to prove the effectiveness of these synthetic approaches.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Co(III)催化 C6 选择性 C-H 活化/吡啶迁移 2-吡啶酮与丙炔酸酯的反应

该研究展示了一种多功能的 Co(III) 催化 C6 选择性 C-H 活化/吡啶迁移 2-吡啶酮与现有丙炔酸酯作为偶联剂的方法。该方法采用廉价的 Co(III) 催化剂，反应条件温和，具有原子经济性高、区域选择性好、官能团耐受性好等特点。此外，为了证明这些合成方法的有效性，还进行了克级合成和药物的后期改性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.

期刊最新文献

Issue Editorial Masthead Issue Publication Information Humupulusones A and B, Two Skeletally Novel Acylphloroglucinol Derivatives from Humulus lupulus. Fully Substituted Cyclobutenes via [2 + 2] Cycloaddition of Ynimines with Cinnamamides Electrochemical Chemo- and Regioselective Reduction of Vicinal Diketones to α-Hydroxy Ketones.