Research progress of extracellular vesicles in the treatment of ovarian diseases (Review).

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental and therapeutic medicine Pub Date : 2023-11-15 DOI:10.3892/etm.2023.12303
Yixin Zhang, Jingyu Zhao, Linqi Han, Zihan Zhang, Caiqin Wang, Wei Long, Kai Meng, Xiaomei Wang
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Abstract

The ovary is an essential reproductive organ in the female organism and its development seriously affects the physical and mental health of female patients. Ovarian diseases include ovarian cancer, premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS). Women should pay attention to the most effective treatments for this condition because it is one of the most prevalent gynecological illnesses at present. Extracellular vesicles (EVs), which are smaller vesicles that mediate the exchange of cellular information, include the three categories of exosomes, microvesicles and apoptotic bodies. They are able to transport proteins, RNA and other substances to adjacent or distal cells, thus allowing cellular and tissue homeostasis to be maintained. Numerous previous studies have revealed that EVs are crucial for the treatment of ovarian diseases. They are known to transport its contents to ovarian cancer cells as well as other ovarian cells such as granulosa cells, affecting the development of ovarian disease processes. Therefore, this extracellular vesicle may be involved as a target in the therapeutic process of ovarian disease and may have great potential in the treatment of ovarian disease. In the present review, the role of EVs in the development of three ovarian diseases, including ovarian cancer, POI and PCOS, was mainly summarizes. It is expected that this will provide some theoretical support for the treatment of ovarian disease.
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细胞外囊泡治疗卵巢疾病的研究进展(综述)。
卵巢是女性机体中重要的生殖器官,它的发育严重影响着女性患者的身心健康。卵巢疾病包括卵巢癌、卵巢早衰(POI)和多囊卵巢综合征(PCOS)。由于卵巢疾病是目前最常见的妇科疾病之一,因此女性应关注最有效的治疗方法。细胞外囊泡(EVs)是介导细胞信息交换的较小囊泡,包括外泌体、微囊泡和凋亡体三大类。它们能够将蛋白质、核糖核酸和其他物质运送到邻近或远端细胞,从而维持细胞和组织的平衡。以往的大量研究表明,EVs 对卵巢疾病的治疗至关重要。众所周知,它们能将其内容物运送到卵巢癌细胞以及颗粒细胞等其他卵巢细胞,影响卵巢疾病的发展过程。因此,这种细胞外囊泡可能是卵巢疾病治疗过程中的一个靶点,在治疗卵巢疾病方面具有巨大潜力。本综述主要总结了 EVs 在三种卵巢疾病(包括卵巢癌、卵巢炎和多囊卵巢综合征)发病过程中的作用。希望能为卵巢疾病的治疗提供一些理论支持。
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来源期刊
Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
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