Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental and therapeutic medicine Pub Date : 2023-11-23 DOI:10.3892/etm.2023.12318
Zhou Sun, Kejing Zhu, Guofu Liang, Fu Yan, Sheng Chao, Lei Jia, Yulin Niu
{"title":"Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.","authors":"Zhou Sun, Kejing Zhu, Guofu Liang, Fu Yan, Sheng Chao, Lei Jia, Yulin Niu","doi":"10.3892/etm.2023.12318","DOIUrl":null,"url":null,"abstract":"The effect of vitamin K on clinical outcomes in patients receiving kidney transplantation is contested according to previous studies. This meta-analysis aimed to summarize the impact of vitamin K on all-cause mortality, renal function, inflammation, and vascular/bone health in patients receiving kidney transplantation. EMBASE, PubMed, and Cochrane were searched for literature concerning the effect of vitamin K on clinical outcomes of patients receiving kidney transplantation until December 2022. Normal vitamin K status/vitamin K supplementation was considered as the experimental group; while vitamin K deficiency/no vitamin K supplementation was considered as the control group. All-cause mortality, renal function indexes, C-reactive protein (CRP), and vascular/bone health indexes were extracted and analyzed. A total of seven studies with 1,101 patients in the experimental group and 651 patients in the control group were included. All-cause mortality was decreased in the experimental group vs. the control group [relative risk (95% confidence interval (CI)]: 0.72 (0.60-0.86), P<0.001]. Regarding renal function indexes, the estimated glomerular filtration rate was increased in the experimental group vs. the control group [mean difference (95% CI): 9.87 (1.48-18.26), P=0.021]; while creatinine and albumin remained unchanged between the two groups (both P>0.05). Moreover, CRP, systolic blood pressure, diastolic blood pressure, triglycerides, hemoglobin, calcium, and 25-hydroxyvitamin D were unchanged between the two groups (all P>0.05). Publication bias was low, and the robustness assessed by sensitivity analysis was generally acceptable. Thus vitamin K exerted a potential implication in reducing all-cause mortality and improving renal function in patients receiving kidney transplantation.","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":"35 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and therapeutic medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/etm.2023.12318","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

The effect of vitamin K on clinical outcomes in patients receiving kidney transplantation is contested according to previous studies. This meta-analysis aimed to summarize the impact of vitamin K on all-cause mortality, renal function, inflammation, and vascular/bone health in patients receiving kidney transplantation. EMBASE, PubMed, and Cochrane were searched for literature concerning the effect of vitamin K on clinical outcomes of patients receiving kidney transplantation until December 2022. Normal vitamin K status/vitamin K supplementation was considered as the experimental group; while vitamin K deficiency/no vitamin K supplementation was considered as the control group. All-cause mortality, renal function indexes, C-reactive protein (CRP), and vascular/bone health indexes were extracted and analyzed. A total of seven studies with 1,101 patients in the experimental group and 651 patients in the control group were included. All-cause mortality was decreased in the experimental group vs. the control group [relative risk (95% confidence interval (CI)]: 0.72 (0.60-0.86), P<0.001]. Regarding renal function indexes, the estimated glomerular filtration rate was increased in the experimental group vs. the control group [mean difference (95% CI): 9.87 (1.48-18.26), P=0.021]; while creatinine and albumin remained unchanged between the two groups (both P>0.05). Moreover, CRP, systolic blood pressure, diastolic blood pressure, triglycerides, hemoglobin, calcium, and 25-hydroxyvitamin D were unchanged between the two groups (all P>0.05). Publication bias was low, and the robustness assessed by sensitivity analysis was generally acceptable. Thus vitamin K exerted a potential implication in reducing all-cause mortality and improving renal function in patients receiving kidney transplantation.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
维生素 K 对改善肾移植后预后的影响:一项荟萃分析。
根据以往的研究,维生素 K 对肾移植患者临床预后的影响存在争议。本荟萃分析旨在总结维生素 K 对肾移植患者全因死亡率、肾功能、炎症和血管/骨骼健康的影响。在 EMBASE、PubMed 和 Cochrane 中检索了截至 2022 年 12 月有关维生素 K 对肾移植患者临床结果影响的文献。将维生素 K 状态正常/补充维生素 K 的患者视为实验组;维生素 K 缺乏/未补充维生素 K 的患者视为对照组。研究人员提取并分析了全因死亡率、肾功能指数、C反应蛋白(CRP)和血管/骨骼健康指数。共纳入七项研究,其中实验组有 1,101 名患者,对照组有 651 名患者。实验组与对照组相比,全因死亡率有所下降[相对风险(95% 置信区间(CI)]:0.72(0.60-0.86),P<0.001]。在肾功能指标方面,实验组与对照组相比,估计肾小球滤过率有所增加[平均差异(95% CI):9.87 (1.48-18.26),P=0.021];而两组间肌酐和白蛋白保持不变(均为 P>0.05)。此外,两组间的 CRP、收缩压、舒张压、甘油三酯、血红蛋白、钙和 25- 羟维生素 D 均无变化(均为 P>0.05)。发表偏倚较低,敏感性分析评估的稳健性基本可以接受。因此,维生素 K 在降低肾移植患者的全因死亡率和改善肾功能方面具有潜在意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
期刊介绍:
期刊最新文献
Off‑label and unapproved pediatric drug utilization: A meta‑analysis. Multivariate analysis of blood parameters for predicting mortality in patients with hip fractures. New insights on the link between Epstein‑Barr virus infection and cognitive decline in neurodegenerative diseases (Review). Peptic ulcer induced by immune checkpoint inhibitors successfully treated with glucocorticoids: A report of three cases and a literature review. Different strategies for treating intracanal fractured instruments in a single tooth: A case report.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1