{"title":"Acute onset of leukemia cutis in a 70-year-old-patient: a case report.","authors":"Maruša Selan, Neža Stopajnik","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We report the case of a 70-year-old man with no significant medical history that presented with a rapid onset of generalized pink to livid papules. No enlarged lymph nodes were observed, and laboratory results revealed a low platelet count. A biopsy was performed, and histopathological examination revealed a cutaneous infiltration with a highly malignant blastoid neoplasm. Further examination performed by hematologists, including cytological analysis of a bone marrow puncture, confirmed acute myelogenous leukemia (AML). Molecular genetic testing revealed a mutation in the gene encoding nucleophosmin (NPM1), the most common genetic anomaly in adult AML. He was treated according to protocol with venetoclax and azacitidine, but he died 4 months post-induction due to infectious complications of febrile neutropenia and subsequent sepsis.</p>","PeriodicalId":45914,"journal":{"name":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","volume":"32 4","pages":"187-189"},"PeriodicalIF":0.6000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Dermatovenerologica Alpina Pannonica et Adriatica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We report the case of a 70-year-old man with no significant medical history that presented with a rapid onset of generalized pink to livid papules. No enlarged lymph nodes were observed, and laboratory results revealed a low platelet count. A biopsy was performed, and histopathological examination revealed a cutaneous infiltration with a highly malignant blastoid neoplasm. Further examination performed by hematologists, including cytological analysis of a bone marrow puncture, confirmed acute myelogenous leukemia (AML). Molecular genetic testing revealed a mutation in the gene encoding nucleophosmin (NPM1), the most common genetic anomaly in adult AML. He was treated according to protocol with venetoclax and azacitidine, but he died 4 months post-induction due to infectious complications of febrile neutropenia and subsequent sepsis.