The evaluation of tibial nerve using shear-wave elastography and ultrasound in patients with systemic sclerosis: A cross-sectional study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-07-04 eCollection Date: 2023-12-01 DOI:10.46497/ArchRheumatol.2023.9835

Serdar Kaymaz, Murat Yiğit, Furkan Ufuk, Burak Sarılar, Uğur Karasu, Veli Çobankara, Nuran Sabir, Hakan Alkan

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Abstract

Objectives: The study aimed to evaluate stiffness and the cross-sectional area (CSA) of the tibial nerve (TN) using shear wave elastography (SWE) and ultrasound (US) and investigate the relationship of these with disease activity, quality of life, and severity of neuropathic pain in patients with systemic sclerosis (SSc).

Patients and methods: This cross-sectional study included 28 SSc patients (1 male, 27 females; mean age: 50±11 years; range, 28 to 67 years) and 22 age- and sex-matched healthy controls (4 males, 18 females; mean age: 48±6 years; range, 37 to 66 years) between March and April 2022. US and SWE were performed on the TN, and CSA and nerve stiffness were measured. The TN was examined by a radiologist, 4 cm proximal to the medial malleolus. A few days later, an evaluation was performed in the second session by a second observer to investigate inter-and intraobserver agreement. Interobserver agreement was evaluated using the intraclass correlation coefficient (ICC). The Scleroderma Health Assessment Questionnaire, European League Against Rheumatism European Scleroderma Trial and Research (EUSTAR) group activity index, and Douleur-Neuropathique 4 scores of the patients were evaluated. Correlations between the questionnaires and measurements of nerve stiffness and CSA were assessed.

Results: Patients with SSc had significantly higher stiffness and CSA values of the right TN compared to healthy controls (p<0.001 and p=0.015, respectively). The nerve stiffness values of the right TN were positively correlated with the EUSTAR activity index (p=0.004, r=0.552). The CSA of the left TN was larger in patients with SSc (21.3±4.9 mm² ) than in controls (12.8±3.4 mm² ), and the nerve elasticity was positively correlated with the EUSTAR activity index (p=0.001, r=0.618). The interobserver agreement was moderate to good for measuring stiffness and CSA of the TN (ICC were 0.660 and 0.818, respectively). There was a good to excellent intraobserver agreement for measuring stiffness and CSA of TN (ICC were 0.843 and 0.940, respectively).

Conclusion: The increased disease activity in patients with SSc is associated with TN involvement, which can be demonstrated by US and SWE.

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使用剪切波弹性成像和超声波评估系统性硬化症患者的胫神经：一项横断面研究。

研究目的该研究旨在使用剪切波弹性成像（SWE）和超声波（US）评估胫神经（TN）的僵硬度和横截面积（CSA），并研究其与系统性硬化症（SSc）患者的疾病活动、生活质量和神经病理性疼痛严重程度之间的关系：这项横断面研究在 2022 年 3 月至 4 月间纳入了 28 名 SSc 患者（1 名男性，27 名女性；平均年龄：50±11 岁；年龄范围：28 至 67 岁）和 22 名年龄和性别匹配的健康对照者（4 名男性，18 名女性；平均年龄：48±6 岁；年龄范围：37 至 66 岁）。对 TN 进行了 US 和 SWE 检查，并测量了 CSA 和神经硬度。放射科医生在距内侧踝骨近端 4 厘米处对 TN 进行了检查。几天后，由另一名观察者进行第二次评估，以调查观察者之间和观察者内部的一致性。观察者之间的一致性采用类内相关系数（ICC）进行评估。对患者的硬皮病健康评估问卷、欧洲抗风湿病联盟欧洲硬皮病试验与研究（EUSTAR）小组活动指数和Douleur-Neuropathique 4评分进行了评估。评估了调查问卷与神经僵硬度和CSA测量值之间的相关性：与健康对照组相比，SSc 患者右侧 TN 的硬度和 CSA 值（p2）明显高于对照组（12.8±3.4 mm2），神经弹性与 EUSTAR 活动指数呈正相关（p=0.001，r=0.618）。在测量 TN 的硬度和 CSA 时，观察者之间的一致性为中等至良好（ICC 分别为 0.660 和 0.818）。在测量TN的硬度和CSA时，观察者内部的一致性为良好至优秀（ICC分别为0.843和0.940）：结论：SSc患者疾病活动度的增加与TN受累有关，US和SWE均可证明这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.