Circular RNA: A promising new star of vaccine.

IF 4.7 2区医学 Q1 MEDICINE, GENERAL & INTERNAL Journal of Translational Internal Medicine Pub Date : 2023-12-20 eCollection Date: 2023-12-01 DOI:10.2478/jtim-2023-0122

Jindong Xie, Fengxi Ye, Xinpei Deng, Yuhui Tang, Jie-Ying Liang, Xufeng Huang, Yuying Sun, Hailin Tang, Jinsong Lei, Shaoquan Zheng, Yutian Zou

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Abstract

Circular RNAs (circRNAs) are a class of single-stranded RNAs with covalently closed structures. Owing to their not having 3' or 5' ends, circRNAs are highly durable and insusceptible to exonuclease-mediated degradation. Moreover, some circRNAs with certain structures are translatable, making them novel vaccines. Vaccines are efficient tools for immunotherapy, such as for the prevention of infectious diseases and cancer treatment. The immune system is activated during immunotherapy to fight against abnormal allies or invaders. CircRNA vaccines represent a potential new avenue in the vaccine era. Recently, several circRNA vaccines have been synthesized and tested in vitro and in vivo. Our review briefly introduces the current understanding of the biology and function of translatable circRNAs, molecular biology, synthetic methods, delivery of circRNA, and current circRNA vaccines. We also discussed the challenges and future directions in the field by summarizing the developments in circRNA vaccines in the past few years.

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环状 RNA：有前途的疫苗新星

环状 RNA（circRNA）是一类具有共价封闭结构的单链 RNA。由于没有 3' 或 5' 末端，circRNA 具有很强的耐久性，不易被外切酶介导的降解。此外，一些具有特定结构的 circRNA 还具有可翻译性，因而成为新型疫苗。疫苗是免疫疗法的有效工具，例如用于预防传染病和治疗癌症。在免疫疗法中，免疫系统被激活，以对抗异常盟友或入侵者。circRNA 疫苗是疫苗时代的一个潜在新途径。最近，已经合成了几种 circRNA 疫苗并进行了体外和体内测试。我们的综述简要介绍了目前对可翻译 circRNA 的生物学和功能、分子生物学、合成方法、circRNA 的传递以及当前 circRNA 疫苗的理解。我们还通过总结过去几年 circRNA 疫苗的发展，讨论了该领域的挑战和未来方向。

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来源期刊

Journal of Translational Internal Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

5.50

自引率

8.20%

发文量