Natural history of infants with vitamin D deficiency in Hong Kong.

IF 1.3 4区医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2023-12-01 DOI:10.6133/apjcn.202312_32(4).0004

Joanna Yuet-Ling Tung, Hung-Kwan So, Keith Tsz-Suen Tung, Rosa Sze-Man Wong, Hing-Wai Tsang, Bianca Chan, Winnie Wan-Yee Tso, Ian Chi-Kei Wong, Jason Cheuk-Sing Yam, Samantha Lai-Ka Lee, Gloria Pang, Wilfred Hing-Sang Wong, Ka-Wang Cheung, Wing-Cheong Leung, Patrick Ip

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Abstract

Background and objectives: The usual recommended intake of vitamin D for healthy infants is 400 international unit (IU) daily. However, a high dose of vitamin D at 2000-3000 IU daily is needed for those with vitamin D deficiency (VDD). This study aimed to assess the natural history of a group of healthy infants with VDD and the associated factors for persistent VDD.

Methods and study design: Healthy infants detected to have VDD (25OHD <25 nmol/L) in a population study were followed, and their demographics and clinical data were collected.

Results: One hundred and thirty-one subjects (boys = 66%) were included. Their first serum 25OHD was taken at a median age of 87.5 days. None were treated with high-dose vitamin D supplements, but some have been given vitamin D at 400 IU daily. They were assessed again at the median age of 252.5 days when 15 remained to have VDD and 26 were in the insufficient range (25 - 49.9nmol/L). All persistent VDD children were on exclusive breastfeeding. Exclusive breastfeeding and no vitamin D supplementation were significant risk factors for persistent vitamin D insufficiency (<50nmol/L).

Conclusions: Persistent VDD is common among infants exclusively breastfeeding and those who did not receive vitamin D supplementation.

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香港婴儿维生素 D 缺乏症的自然病史。

背景和目的：健康婴儿通常建议每天摄入 400 国际单位（IU）的维生素 D。然而，维生素 D 缺乏症（VDD）患者需要每天摄入 2000-3000 国际单位的高剂量维生素 D。本研究旨在评估一组患有维生素 D 缺乏症的健康婴儿的自然病史以及导致维生素 D 缺乏症持续存在的相关因素：方法与研究设计：检测出患有维生素 D 缺乏症的健康婴儿（25OHD 结果：131 名受试者（男孩、女孩、男孩和女孩共纳入 131 名受试者（男孩 = 66%）。他们的首次血清 25OHD 检测的中位年龄为 87.5 天。他们都没有服用大剂量维生素 D 补充剂，但有些人每天服用 400 IU 的维生素 D。他们在 252.5 天的中位年龄时再次接受评估，当时有 15 名儿童仍有 VDD，26 名儿童的血清维生素 D 含量处于不足范围（25 - 49.9nmol/L）。所有持续存在 VDD 的儿童都在接受纯母乳喂养。纯母乳喂养和未补充维生素 D 是导致维生素 D 持续不足的重要风险因素：在纯母乳喂养和未补充维生素 D 的婴儿中，持续维生素 D 不足的情况很常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific journal of clinical nutrition 医学-营养学

CiteScore

2.50

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board