Combining theranostic/particle therapy with immunotherapy for the treatment of GU malignancies

IF 1.6 Q3 UROLOGY & NEPHROLOGY BJUI compass Pub Date : 2023-12-13 DOI:10.1002/bco2.316
Karin A. Skalina, Beata Małachowska, Kunal K. Sindhu, Marcher Thompson, Anthony D. Nehlsen, Lucas Resende Salgado, Zachary Dovey, Shaakir Hasan, Chandan Guha, Justin Tang
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Abstract

Particle therapy and radiopharmaceuticals are emerging fields in the treatment of genitourinary cancers. With these novel techniques and the ever-growing immunotherapy options, the combinations of these therapies have the potential to improve current cancer cure rates. However, the most effective sequence and combination of these therapies is unknown and is a question that is actively being explored in multiple ongoing clinical trials. Here, we review the immunological effects of particle therapy and the available radiopharmaceuticals and discuss how best to combine these therapies.

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将治疗仪/粒子疗法与免疫疗法结合起来治疗上咽部恶性肿瘤
粒子疗法和放射性药物是治疗泌尿生殖系统癌症的新兴领域。有了这些新技术和不断增加的免疫疗法选择,这些疗法的组合有可能提高目前的癌症治愈率。然而,这些疗法的最有效序列和组合尚不清楚,也是多个正在进行的临床试验中积极探索的问题。在此,我们回顾了粒子疗法和现有放射性药物的免疫学效应,并讨论了如何最好地结合这些疗法。
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CiteScore
2.30
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0.00%
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审稿时长
12 weeks
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