Pregnancy-related breast cancer: 14-year experience in a tertiary institution in Hong Kong

Billy Ho Hung Cheung , Vivian Chi Mei Man , Goby Tze Wa Sham , Lorraine Chow , Michael Co , Ava Kwong
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Abstract

Background

The incidence of pregnancy-associated breast cancer (PABC) is increasing. Its tumor characteristics and overall survival compared with those in nonpregnant patients remain controversial. While there have been suggestions that PABC patients have a 40 % increase in the risk of death compared to non-pregnant patients, other studies suggested similar disease outcomes. This study aims to review our local experience with PABC.

Methods

Twenty-eight patients diagnosed with PABC and twenty-eight patients diagnosed at premenopausal age randomly selected by a computer-generated system during the same period were recruited. Background characteristics, tumor features, and survival were compared.

Results

Among the twenty-eight pregnant patients, seventeen were diagnosed during pregnancy, and eleven were diagnosed in the postpartum period. Compared to the non-pregnant breast cancer patients, they presented with less progesterone receptor-positive tumor (35.7 % vs. 64.2 %, p = 0.03). Although there was no statistically significant difference in tumor size (p = 0.44) and nodal status (p = 0.16), the tumor tended to be larger in size (2.94 +/− 1.82 vs 2.40 +/− 1.69 cm) and with more nodal involvement (35.7 % vs 25.0 %). There was also a trend of delayed presentation to medical attention, with a mean duration of 13.1 weeks in the PABC group and 8.6 weeks in the control group. However, the overall survival did not differ (p = 0.63).

Conclusion

PABC is increasing in incidence. They tend to have more aggressive features, but overall survival remains similar. A multidisciplinary approach is beneficial for providing the most appropriate care.

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与妊娠有关的乳腺癌:香港一家三级医疗机构的 14 年经验
背景妊娠相关性乳腺癌(PABC)的发病率正在上升。与非妊娠患者相比,其肿瘤特征和总体生存率仍存在争议。虽然有观点认为 PABC 患者的死亡风险比非妊娠患者增加了 40%,但其他研究也显示了类似的疾病结果。本研究旨在回顾我们当地在 PABC 方面的经验。方法招募了 28 名确诊为 PABC 的患者和 28 名通过计算机生成系统随机选择的同期绝经前年龄的患者。结果 在 28 名妊娠期患者中,17 人在妊娠期确诊,11 人在产后确诊。与非妊娠期乳腺癌患者相比,她们的孕酮受体阳性肿瘤较少(35.7% 对 64.2%,P = 0.03)。虽然在肿瘤大小(p = 0.44)和结节状态(p = 0.16)方面没有统计学意义上的显著差异,但肿瘤往往更大(2.94 +/- 1.82 vs 2.40 +/- 1.69 cm),结节受累更多(35.7 % vs 25.0 %)。就医时间也有延迟的趋势,PABC 组的平均就医时间为 13.1 周,对照组为 8.6 周。结论 PABC 的发病率呈上升趋势。PABC的发病率越来越高,其特点往往更具侵袭性,但总生存率仍然相似。多学科方法有利于提供最适当的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
148
审稿时长
56 days
期刊介绍: Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.
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