The coexistence of narcolepsy and multiple sclerosis: A case report

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system, characterized by myelin degeneration. Aside from general symptoms such as visual impairment, muscle weakness, and sensory abnormalities, sleep disorders are sometimes experienced by MS patients. Here, we report a rare case of a 21-year-old young male patient presenting with both MS and narcolepsy. Moreover, we also reviewed the potential pathophysiological mechanisms that linked these two diseases, including the involvement of the immune system and neuronal damage. This case report emphasized the significance of further research into the relationship between MS and narcolepsy and provided a valuable theoretical basis that MS might be a key cause of narcolepsy. In addition, therapeutic strategies for MS, such as ofatumumab, might help alleviate narcolepsy.