Separation, identification and anti-Breast cancer efficacy of anthocyanin of Melia dubia bark

IF 2.2 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Letters: X Pub Date : 2023-12-14 DOI:10.1016/j.mlblux.2023.100223

G. Dayana Jeyaleela , J. Rosaline Vimala

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Abstract

Numerous antioxidants were extensively found in many plants at different levels which are associated with the therapeutic importance of medicinal plants. The therapeutic impact of the traditional plants Melia dubia's leaves was previously thoroughly explored. The current investigation aimed to examine the biological application of natural antioxidants in the bark extract of Melia Dubia and their effect on breast cancer cells by MTT test. Preliminary phytochemical analysis of six extracts of Melia dubia bark was tested. Anthocyanine compound MDB-1 (isolated compound) is separated from the potential extract (methanol) by combined chromatography methods. On In-vitro analysis, the IC₅₀ value of MDB-1 on the MCF7 cell line is 18.32 µg/ml which exhibits a cytotoxicity effect on the breast cancer cells. The isolated compound MDB-1 will be further used to develop drug formulations to overcome world challenges in cancer treatment.

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杜鹃树皮花青素的分离、鉴定和抗乳腺癌功效

在许多植物中广泛发现了不同程度的多种抗氧化剂，这与药用植物的治疗重要性有关。以前曾深入研究过传统植物 Melia dubia 叶子的治疗作用。目前的研究旨在通过 MTT 测试，检验天然抗氧化剂在杜比树皮提取物中的生物应用及其对乳腺癌细胞的影响。研究人员对杜鹃树皮的六种提取物进行了初步的植物化学分析。花青素化合物 MDB-1（分离化合物）通过组合色谱法从潜在提取物（甲醇）中分离出来。在体外分析中，MDB-1 对 MCF7 细胞株的 IC50 值为 18.32 µg/ml，显示出对乳腺癌细胞的细胞毒性作用。分离出的化合物 MDB-1 将进一步用于开发药物制剂，以攻克癌症治疗领域的世界性难题。

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