Antimalarial Properties of Sida cordifolia L. Leaf Extract in Mice: Survivability Depends Less on Parasitaemia Suppression

Samuel Ansong, Desmond Nkrumah, Reinhard Isaac Nketia, Samuel Oppong Bekoe, Abena Amponsaa Brobbey, Evelyn Asante-Kwatia, Gustav Komlaga
{"title":"Antimalarial Properties of Sida cordifolia L. Leaf Extract in Mice: Survivability Depends Less on Parasitaemia Suppression","authors":"Samuel Ansong, Desmond Nkrumah, Reinhard Isaac Nketia, Samuel Oppong Bekoe, Abena Amponsaa Brobbey, Evelyn Asante-Kwatia, Gustav Komlaga","doi":"10.1155/2023/5560711","DOIUrl":null,"url":null,"abstract":"<i>Sida cordifolia</i> has been used to treat malaria in Ghana albeit without scientific evidence of antimalarial activity and safety. This work aimed to assess the antimalarial properties and acute toxicity of the aqueous leaf extract of <i>S. cordifolia</i> in murine models. Aqueous extract of the plant was analysed for both suppressive and curative antimalarial properties in chloroquine-sensitive ANKA strains of rodent <i>Plasmodium berghei</i>-infected mice. Acute toxicity evaluation was performed in rats according to the OECD 425 guidelines. The extract displayed antiplasmodial activity <i>in vivo</i> with ED<sub>50</sub> of 117.49 ± 15.22 mg/kg and 144.84 ± 18.17 mg/kg in suppressive and curative studies, respectively. The highest % parasitaemia suppression exerted was 76.90 ± 0.64% and 61.50 ± 0.97%, respectively, in the suppressive and curative studies. Survival of infected mice treated with the extract was significantly prolonged. This was dependent on the dose of the extract but imperfectly related to the % parasitaemia suppression. Related antimalarial parameters including percentage hematocrit, changes in body weight, and temperature of experimental mice indicated alleviation of malarial symptoms of treated animals. The extract did not show toxicity in rats. <i>Sida cordifolia</i> L. has antimalarial properties, and was safe. It suppressed parasitaemia in both suppressive and curative studies, was not toxic to animals and prolonged the life of infected animals under treatment. This, therefore, justifies the traditional use of <i>S. cordifolia</i> for the treatment of malaria in Ghana.","PeriodicalId":12236,"journal":{"name":"Evidence-based Complementary and Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evidence-based Complementary and Alternative Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2023/5560711","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Sida cordifolia has been used to treat malaria in Ghana albeit without scientific evidence of antimalarial activity and safety. This work aimed to assess the antimalarial properties and acute toxicity of the aqueous leaf extract of S. cordifolia in murine models. Aqueous extract of the plant was analysed for both suppressive and curative antimalarial properties in chloroquine-sensitive ANKA strains of rodent Plasmodium berghei-infected mice. Acute toxicity evaluation was performed in rats according to the OECD 425 guidelines. The extract displayed antiplasmodial activity in vivo with ED50 of 117.49 ± 15.22 mg/kg and 144.84 ± 18.17 mg/kg in suppressive and curative studies, respectively. The highest % parasitaemia suppression exerted was 76.90 ± 0.64% and 61.50 ± 0.97%, respectively, in the suppressive and curative studies. Survival of infected mice treated with the extract was significantly prolonged. This was dependent on the dose of the extract but imperfectly related to the % parasitaemia suppression. Related antimalarial parameters including percentage hematocrit, changes in body weight, and temperature of experimental mice indicated alleviation of malarial symptoms of treated animals. The extract did not show toxicity in rats. Sida cordifolia L. has antimalarial properties, and was safe. It suppressed parasitaemia in both suppressive and curative studies, was not toxic to animals and prolonged the life of infected animals under treatment. This, therefore, justifies the traditional use of S. cordifolia for the treatment of malaria in Ghana.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Sida cordifolia L. 叶提取物在小鼠体内的抗疟特性:存活率较少依赖于寄生虫血症抑制作用
在加纳,Sida cordifolia 一直被用于治疗疟疾,尽管没有抗疟活性和安全性的科学证据。这项研究旨在评估 Sida cordifolia 的水性叶提取物在小鼠模型中的抗疟特性和急性毒性。在对氯喹敏感的 ANKA 株系啮齿动物疟原虫感染小鼠中,对该植物的水提取物进行了抑制性和治疗性抗疟特性分析。根据 OECD 425 准则,对大鼠进行了急性毒性评估。该提取物显示出体内抗疟活性,在抑制性和治疗性研究中,ED50 分别为 117.49 ± 15.22 mg/kg 和 144.84 ± 18.17 mg/kg。在抑制性和治疗性研究中,最高的寄生虫血症抑制率分别为 76.90 ± 0.64% 和 61.50 ± 0.97%。用提取物治疗的受感染小鼠的存活时间明显延长。这与提取物的剂量有关,但与寄生虫血症抑制率的关系并不十分密切。相关的抗疟参数,包括实验小鼠的血细胞比容百分比、体重变化和体温,都表明治疗动物的疟疾症状有所缓解。该提取物对大鼠没有毒性。Sida cordifolia L. 具有抗疟特性,并且是安全的。在抑制性和治疗性研究中,它都能抑制寄生虫血症,对动物无毒性,并能延长接受治疗的受感染动物的寿命。因此,这证明加纳传统上使用 Sida cordifolia 治疗疟疾是正确的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Evidence-based Complementary and Alternative Medicine
Evidence-based Complementary and Alternative Medicine 医学-全科医学与补充医学
自引率
0.00%
发文量
1983
审稿时长
2.2 months
期刊介绍: Evidence-Based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine. The journal seeks to apply scientific rigor to the study of complementary and alternative medicine (CAM) modalities, particularly traditional Asian healing systems. eCAM emphasizes health outcome, while documenting biological mechanisms of action. The journal is devoted to the advancement of science in the field of basic research, clinical studies, methodology or scientific theory in diverse areas of Biomedical Sciences. The journal does not consider articles on homeopathy.
期刊最新文献
Retracted: Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway. Evaluation of In Vivo Antidiarrheal Activities of 80% Methanol Extract and Solvent Fractions of Peels of Colocasia esculenta (Araceae). Anti-Helicobacter pylori Effects of Thymus caramanicus Jalas Essential Oils: A New Antimicrobial Approach. Antibacterial and Antioxidant Compounds from the Root Extract of Aloe debrana. Evaluation of In Vitro Antimicrobial, Cytotoxic, Thrombolytic, and Antiarthritic Property of Different Parts of Bari Orchid
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1