Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19

IF 1 Q4 ENDOCRINOLOGY & METABOLISM Diabetes epidemiology and management Pub Date : 2024-01-01 DOI:10.1016/j.deman.2023.100194

Lind Alexander , Cao Yang , Hesser Hugo , Hårdstedt Maria , Jansson Stefan , Lernmark Åke , Sundqvist Martin , Tevell Staffan , Tsai Cheng-ting , Wahlberg Jeanette , Jendle Johan

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Abstract

Aims

The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic.

Methods

Via randomization, individuals living with diabetes T1D (n = 203) and T2D (n = 413), were identified during February-July 2021 through health-care registers. Population controls (n = 282) were matched for age, gender, and residential area. Questionnaires included self-assessment of anxiety, depression, QoL, and demographics in relation to SARS-CoV-2 exposure. Blood was collected through home-capillary sampling, and SARS-CoV-2 Nucleocapsid (NCP) and Spike antibodies (SC2_S1) were determined by multiplex Antibody Detection by Agglutination-PCR (ADAP) assays.

Results

Younger age and health issues were related to anxiety, depression, and QoL, with no differences between the study groups. Female gender was associated with anxiety, while obesity was associated with lower QoL. The SARS‑CoV‑2 NCP seroprevalence was higher in T1D (8.9 %) compared to T2D (3.9 %) and controls (4.0 %), while the SARS‑CoV‑2 SC2_S1 seroprevalence was higher for controls (25.5 %) compared to T1D (16.8 %) and T2D (14.0 %).

Conclusions

A higher SARS‑CoV‑2 infection rate in T1D may be explained by younger age and higher employment rate, and the associated increased risk for viral exposure.

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COVID-19 第二波期间糖尿病患者的焦虑、抑郁和生活质量与 SARS-CoV-2 抗体的关系

目的比较 COVID-19 大流行第二波期间 1 型（T1D）和 2 型（T2D）糖尿病患者与匹配对照组的焦虑、抑郁和生活质量（QoL）。方法在 2021 年 2 月至 7 月期间，通过医疗保健登记册随机确定 T1D（n = 203）和 T2D（n = 413）糖尿病患者。人群对照组（n = 282）的年龄、性别和居住地区均匹配。调查问卷包括焦虑、抑郁、生活质量以及与 SARS-CoV-2 暴露相关的人口统计学方面的自我评估。通过家庭毛细管采血，用凝集-PCR（ADAP）多重抗体检测法测定 SARS-CoV-2 核头壳抗体（NCP）和尖峰抗体（SC2_S1）。女性性别与焦虑有关，而肥胖则与较低的 QoL 有关。结论T1D的SARS-CoV-2 NCP血清阳性率（8.9%）高于T2D（3.9%）和对照组（4.0%），而对照组的SARS-CoV-2 SC2_S1血清阳性率（25.5%）高于T1D（16.8%）和T2D（14.0%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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