Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Current drug targets Pub Date : 2023-12-23 DOI:10.2174/0113894501272740231219072525

Mohammad Ali Goudarzi, Zahra Sohrabi, Mohammad Hashem Hashempur, Saeed Nosratabadi, Zahra Namkhah, Cain C. T. Clark, Neda Haghighat

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Abstract

Introduction:: There is a growing interest in the considerable benefits of grape products intake, as some studies have indicated that they may improve cardiometabolic risk factors. However, the widespread impact of grape products on the anthropometric indices is not fully resolved. Method:: The purpose of this systematic review and meta-analysis was to examine the effects of grape products intake on anthropometric indices in adults. Randomized controlled trials (RCT) examining the effects of grape products intake on anthropometric indices, published up to December 2021, were identified through PubMed, SCOPUS, and ISI Web of Science databases. 30 studies with 35 effect sizes, including 1284 participants (708 cases and 576 controls), were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence interval (CI). Result:: The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used. Conclusion:: Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.

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葡萄产品的摄入量是否会影响成年人的体重？随机对照试验的系统回顾和元分析

导言一些研究表明，摄入葡萄制品可改善心脏代谢风险因素，因此人们对摄入葡萄制品的巨大益处越来越感兴趣。然而，葡萄制品对人体测量指数的广泛影响尚未完全解决。方法：本系统综述和荟萃分析的目的是研究摄入葡萄制品对成年人人体测量指数的影响。通过 PubMed、SCOPUS 和 ISI Web of Science 数据库查找了截至 2021 年 12 月发表的研究葡萄制品摄入量对人体测量指数影响的随机对照试验（RCT）。共纳入 30 项研究，35 个效应大小，包括 1284 名参与者（708 例病例和 576 例对照），并使用随机效应模型进行分析，计算加权平均差 (WMD) 和 95% 置信区间 (CI)。结果结果表明，摄入葡萄产品可显著降低肥胖参与者的体重（p = 0.001）和体重指数（p = 0.004），而且使用葡萄籽提取物时效果更佳。结论我们的研究表明，摄入葡萄产品有助于降低肥胖者的体重。今后还需要进行持续时间更长、肥胖人群更多的大型 RCT 研究，以扩展我们的研究结果。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.