S90 Pediatric Atrophic Metaplastic Gastritis: A Rare Presentation of IPEX Syndrome

Alicia Olave-Pichon, Nishaben Patel
{"title":"S90 Pediatric Atrophic Metaplastic Gastritis: A Rare Presentation of IPEX Syndrome","authors":"Alicia Olave-Pichon, Nishaben Patel","doi":"10.14309/01.ajg.0000996104.82359.a7","DOIUrl":null,"url":null,"abstract":".Thiscaseseriespresented4patientswithCDwhoreceivedsirolimustherapyforaprimaryindicationofrefractoryCD.Allpatientshadfailedtreatmentwithatleast6otherIBD-therapies. Our results reveal 1 of 4 patients reporting symptomatic improvement and whilst treatment escalation was not required, imaging measures of in fl ammation remained equivocal. Furthermore, all 4 patients required sirolimus discontinuation due to adverse e ff ects. With minimal data currently available for use of sirolimus therapy in adults with refractory IBD, our fi ndings suggest that its role may be limited by treatment-derived adverse e ff ects. Further large-scale studies are needed to investigate the e ffi ciency of sirolimus therapy in refractory IBD, with particular attention to treatment-limiting adverse e ff ects.","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"596 ","pages":"S25 - S25"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American Journal of Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14309/01.ajg.0000996104.82359.a7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

.Thiscaseseriespresented4patientswithCDwhoreceivedsirolimustherapyforaprimaryindicationofrefractoryCD.Allpatientshadfailedtreatmentwithatleast6otherIBD-therapies. Our results reveal 1 of 4 patients reporting symptomatic improvement and whilst treatment escalation was not required, imaging measures of in fl ammation remained equivocal. Furthermore, all 4 patients required sirolimus discontinuation due to adverse e ff ects. With minimal data currently available for use of sirolimus therapy in adults with refractory IBD, our fi ndings suggest that its role may be limited by treatment-derived adverse e ff ects. Further large-scale studies are needed to investigate the e ffi ciency of sirolimus therapy in refractory IBD, with particular attention to treatment-limiting adverse e ff ects.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
S90 小儿萎缩性变性胃炎:IPEX综合征的一种罕见表现形式
所有患者均接受过至少6种其他IBD治疗失败。我们的研究结果显示,4名患者中有1名患者的症状有所改善,虽然不需要升级治疗,但内翻的影像学指标仍然不明确。此外,所有4名患者都因不良反应而需要停用西罗莫司。目前,关于西罗莫司治疗成人难治性IBD的数据极少,我们的研究结果表明,西罗莫司的作用可能会受到来自治疗的不良反应的限制。我们需要进一步开展大规模研究,探讨西罗莫司治疗难治性IBD的疗效,尤其要关注限制治疗的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
S50 Delayed Micro-Perforation Following Endoscopic Stricturotomy: A Rare Complication Managed Medically S42 Tailoring Crohn’s Disease Surveillance After Ileocolic Resection: The Importance of Inflammatory Biomarkers S70 Real-World Experience and Perspectives on the Treatment of Crohn’s Disease: Results From a Health Care Provider Survey S60 Bone Marrow Transplant for the Treatment of Multiple Sclerosis Triggered by Anti-TNF Therapy and Crohn‘s Disease S51 Patient-Reported Impact of Irritable Bowel Disease and Desired Treatment Outcomes Desired Treatment Outcomes
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1