Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk

IF 5 3区 医学 Q1 GENETICS & HEREDITY Genes and immunity Pub Date : 2023-12-23 DOI:10.1038/s41435-023-00249-0
Maxime Rotival, Lluis Quintana-Murci
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环境变异和遗传多样性导致人群对 SARS-CoV-2 和 COVID-19 风险的免疫反应存在差异
COVID-19 大流行揭示了感染 SARS-CoV-2 的个体之间存在着相当大的临床差异,从无症状病例到致命结局不等[1]。影响这种差异的因素包括高龄、男性、合并症和人类遗传学[1, 2]。具体而言,针对 I 型干扰素(IFNs)的先天性错误或自身抗体已被确定为导致 COVID-19 肺炎严重程度的重要因素 [2]。此外,涉及 20 多万病例和 300 多万对照的全基因组关联研究(GWAS)确定了 51 个与 SARS-CoV-2 感染易感性或 COVID-19 严重程度相关的不同基因位点,强调了人类遗传因素在该疾病病理生理学中的重要作用[3]。
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来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
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